SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 432
PHE A 327
MET A 345
ALA A 344
 None
 1.24A 1linA-4nscA:
2.2		 1linA-4nscA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJY_H_BEZH306_0
(ANTIBODY 7A1 FAB')		 4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASN A 116
ALA A 120
ARG A 119
TYR A 334
 None
 1.42A 2ajyH-4nscA:
undetectable		 2ajyH-4nscA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AK1_H_BEZH401_0
(ANTIBODY 7A1 FAB')		 4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASN A 116
ALA A 120
ARG A 119
TYR A 334
 None
 1.41A 2ak1H-4nscA:
undetectable		 2ak1H-4nscA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 252
THR A 214
PHE A 206
 None
 0.64A 2x91A-4nscA:
undetectable		 2x91A-4nscA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 365
GLU A 298
ASP A 235
THR A 292
 None
 1.11A 4uacA-4nscA:
undetectable		 4uacA-4nscA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE A 299
PHE A 223
PHE A 296
VAL A 215
 None
 1.16A 5a1rA-4nscA:
undetectable		 5a1rA-4nscA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A 399
LEU A 428
ASN A 373
ASP A 376
 None
 0.83A 5vcyA-4nscA:
undetectable		 5vcyA-4nscA:
26.18