SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nsd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4nsd CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A 211
SER A 205
PHE A 282
ALA A 277
 None
 1.04A 1fxvA-4nsdA:
undetectable
1fxvB-4nsdA:
undetectable		 1fxvA-4nsdA:
21.37
1fxvB-4nsdA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4nsd CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 337
LEU A 371
PHE A 417
ILE A 374
PHE A 370
 None
 1.41A 1skxA-4nsdA:
undetectable		 1skxA-4nsdA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4nsd CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PHE A 195
GLU A 150
VAL A 153
ILE A 156
ILE A 210
 None
 1.22A 2dg3A-4nsdA:
undetectable		 2dg3A-4nsdA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4nsd CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 423
GLU A 427
GLY A 426
 CA  A 502 (-2.8A)
None
None
 0.71A 3w9tA-4nsdA:
undetectable		 3w9tA-4nsdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4nsd CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 208
THR A 214
SER A 205
PHE A 206
 None
 1.04A 4ac9C-4nsdA:
undetectable		 4ac9C-4nsdA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4nsd CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 380
GLN A 398
THR A 402
 None
 0.73A 5n0oA-4nsdA:
undetectable		 5n0oA-4nsdA:
22.63