SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nsp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		5 / 11 GLY A 129
GLY A 212
ILE A 209
TYR A 208
PRO A 206
 None
 1.11A 1p91A-4nspA:
undetectable		 1p91A-4nspA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		4 / 8 LEU A  70
VAL A  48
GLY A  49
VAL A 153
 None
 0.91A 2a1oA-4nspA:
undetectable		 2a1oA-4nspA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		4 / 8 PHE A 136
VAL A  28
ASN A 128
GLY A 129
 None
 0.88A 3hjoB-4nspA:
undetectable		 3hjoB-4nspA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		4 / 8 PHE A 136
VAL A  28
VAL A 125
GLY A 129
 None
 0.74A 3hjoB-4nspA:
undetectable		 3hjoB-4nspA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		5 / 9 PHE A 136
VAL A  28
VAL A 125
ASN A 128
GLY A 129
 None
 0.92A 3km6B-4nspA:
undetectable		 3km6B-4nspA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		4 / 7 PHE A 136
VAL A  28
ASN A 128
GLY A 129
 None
 0.92A 3kmoB-4nspA:
undetectable		 3kmoB-4nspA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		5 / 12 ASN A 128
GLY A 194
GLY A 152
LEU A 186
PHE A 183
 None
 1.39A 3r24A-4nspA:
undetectable		 3r24A-4nspA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		4 / 5 ILE A 209
ARG A 222
ASP A  32
VAL A 130
 None
 1.22A 4nkxC-4nspA:
undetectable		 4nkxC-4nspA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		4 / 5 ILE A 209
ARG A 222
ASP A  32
VAL A 130
 None
 1.24A 4nkxD-4nspA:
undetectable		 4nkxD-4nspA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		5 / 12 LEU A 193
GLY A 137
ASP A 126
GLU A 100
ALA A  97
 None
 1.16A 4pclA-4nspA:
undetectable		 4pclA-4nspA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		5 / 12 ALA A 154
GLY A 143
GLY A 129
LEU A 131
GLY A  50
 None
 0.92A 5i73A-4nspA:
undetectable		 5i73A-4nspA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4nsp ENDONUCLEASE V
(Homo
sapiens) 		5 / 12 LEU A 124
GLY A  50
VAL A 236
GLY A 152
LEU A 223
 None
 0.97A 5xv7A-4nspA:
undetectable		 5xv7A-4nspA:
15.65