SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4nsq HISTONE
ACETYLTRANSFERASE
KAT2B
(Homo
sapiens) 		3 / 3 PRO A 530
MET A 529
TYR A 533
 None
 0.90A 4qa0B-4nsqA:
undetectable		 4qa0B-4nsqA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4nsq HISTONE
ACETYLTRANSFERASE
KAT2B
(Homo
sapiens) 		3 / 3 PRO A 530
MET A 529
TYR A 533
 None
 0.93A 4qa0A-4nsqA:
undetectable		 4qa0A-4nsqA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4nsq HISTONE
ACETYLTRANSFERASE
KAT2B
(Homo
sapiens) 		3 / 3 PRO A 530
MET A 529
TYR A 533
 None
 0.99A 4qa2B-4nsqA:
undetectable		 4qa2B-4nsqA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4nsq HISTONE
ACETYLTRANSFERASE
KAT2B
(Homo
sapiens) 		5 / 12 ILE A 549
LEU A 518
GLY A 517
ALA A 575
VAL A 576
 None
None
None
COA  A 700 (-3.9A)
COA  A 700 (-4.1A)
 0.74A 5x66F-4nsqA:
undetectable		 5x66F-4nsqA:
20.49