SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 7 THR A 611
TRP A 612
GLY A 622
ASP A 669
 None
 0.98A 1bu5A-4nsxA:
undetectable		 1bu5A-4nsxA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  66
THR A  65
ARG A 344
VAL A 311
 None
 0.89A 1ekjF-4nsxA:
undetectable
1ekjG-4nsxA:
undetectable		 1ekjF-4nsxA:
16.46
1ekjG-4nsxA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 284
LEU A 273
LEU A 287
ILE A 310
PHE A 256
 None
 0.89A 1fmlB-4nsxA:
undetectable		 1fmlB-4nsxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 230
GLY A 228
ILE A 246
THR A 210
SER A 269
 None
 1.22A 1gtnL-4nsxA:
undetectable
1gtnM-4nsxA:
undetectable		 1gtnL-4nsxA:
6.52
1gtnM-4nsxA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 135
ILE A 162
ASN A 187
THR A 184
 None
 1.03A 1h7xA-4nsxA:
undetectable		 1h7xA-4nsxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 135
ILE A 162
ASN A 187
THR A 184
 None
 1.02A 1h7xB-4nsxA:
undetectable		 1h7xB-4nsxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 135
ILE A 162
ASN A 187
THR A 184
 None
 1.03A 1h7xC-4nsxA:
undetectable		 1h7xC-4nsxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 135
ILE A 162
ASN A 187
THR A 184
 None
 1.03A 1h7xD-4nsxA:
undetectable		 1h7xD-4nsxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 484
VAL A 505
ALA A 559
GLY A 527
TYR A 529
 None
 1.21A 1kiaB-4nsxA:
undetectable		 1kiaB-4nsxA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.63A 1usqA-4nsxA:
undetectable		 1usqA-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.62A 1usqB-4nsxA:
undetectable		 1usqB-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.64A 1usqC-4nsxA:
undetectable		 1usqC-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.62A 1usqD-4nsxA:
undetectable		 1usqD-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.63A 1usqE-4nsxA:
undetectable		 1usqE-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 5 CYH A 652
PRO A 352
THR A  57
THR A 681
 None
 1.49A 1ymxB-4nsxA:
undetectable		 1ymxB-4nsxA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 221
ILE A 246
ILE A 209
LEU A 278
 None
 0.92A 1zgyA-4nsxA:
undetectable		 1zgyA-4nsxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.59A 2jkjA-4nsxA:
undetectable		 2jkjA-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.59A 2jkjB-4nsxA:
undetectable		 2jkjB-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.60A 2jkjC-4nsxA:
undetectable		 2jkjC-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.61A 2jklA-4nsxA:
undetectable		 2jklA-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.61A 2jklB-4nsxA:
undetectable		 2jklB-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.63A 2jklC-4nsxA:
undetectable		 2jklC-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.61A 2jklD-4nsxA:
undetectable		 2jklD-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 538
ILE A 525
GLY A 527
TYR A 529
 None
 0.61A 2jklF-4nsxA:
undetectable		 2jklF-4nsxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 487
ALA A 467
GLY A 475
GLY A 472
THR A 485
 None
 1.14A 2okcA-4nsxA:
undetectable		 2okcA-4nsxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 581
GLY A 583
ILE A 588
ILE A 567
 None
 0.87A 2q9rA-4nsxA:
undetectable		 2q9rA-4nsxA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 7 SER A 265
PHE A  39
ILE A 310
GLY A 297
 None
 0.98A 2v0mC-4nsxA:
undetectable		 2v0mC-4nsxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  93
LEU A 112
LEU A 128
ILE A 137
LEU A 180
 None
 1.16A 3hj3B-4nsxA:
undetectable		 3hj3B-4nsxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 THR A 243
VAL A 266
GLY A 267
LEU A 273
ILE A 209
 None
 1.01A 3ijdA-4nsxA:
undetectable		 3ijdA-4nsxA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 587
HIS A 501
ASP A 563
LEU A 562
LEU A 540
 None
 1.28A 3lcvB-4nsxA:
undetectable		 3lcvB-4nsxA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 507
GLY A 527
ASP A 556
TYR A 498
ILE A 484
 None
 0.91A 3prsA-4nsxA:
undetectable		 3prsA-4nsxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 540
VAL A 526
PHE A 558
VAL A 577
 None
 1.07A 3soaA-4nsxA:
2.1		 3soaA-4nsxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 124
CYH A 122
HIS A 172
 None
 1.29A 3u9fL-4nsxA:
undetectable		 3u9fL-4nsxA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 245
ILE A 246
VAL A 266
LEU A 264
 None
 1.08A 4em2A-4nsxA:
undetectable		 4em2A-4nsxA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_C_ACTC301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 317
TYR A  61
TRP A 376
ARG A 346
 None
 1.49A 4g19C-4nsxA:
0.0		 4g19C-4nsxA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 SER A  34
PRO A  38
GLN A 300
ASP A 272
GLY A 267
 None
 1.35A 4j7xA-4nsxA:
undetectable		 4j7xA-4nsxA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 SER A  34
PRO A  38
GLN A 300
ASP A 272
GLY A 267
 None
 1.38A 4j7xF-4nsxA:
undetectable		 4j7xF-4nsxA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 614
LEU A 560
PHE A 558
ASP A 556
ASP A 511
 None
 1.37A 4j7xJ-4nsxA:
undetectable		 4j7xJ-4nsxA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 4 SER A 682
GLY A  99
GLU A 111
 None
 0.57A 4juoA-4nsxA:
undetectable
4juoC-4nsxA:
undetectable		 4juoA-4nsxA:
21.28
4juoC-4nsxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.77A 4k8cA-4nsxA:
undetectable		 4k8cA-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.75A 4kahA-4nsxA:
undetectable		 4kahA-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.75A 4kahB-4nsxA:
undetectable		 4kahB-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.77A 4kanA-4nsxA:
undetectable		 4kanA-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.77A 4kanB-4nsxA:
undetectable		 4kanB-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.76A 4kbeA-4nsxA:
undetectable		 4kbeA-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.76A 4kbeB-4nsxA:
undetectable		 4kbeB-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.76A 4lbgA-4nsxA:
undetectable		 4lbgA-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 350
TYR A 295
PRO A 353
 None
 0.76A 4lbgB-4nsxA:
undetectable		 4lbgB-4nsxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		4 / 5 SER A 151
GLU A 107
LYS A 102
ASP A 147
 None
 1.44A 4pclA-4nsxA:
undetectable		 4pclA-4nsxA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  93
LEU A 112
LEU A 128
ILE A 137
LEU A 180
 None
 1.15A 4q0dA-4nsxA:
undetectable		 4q0dA-4nsxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  93
LEU A 112
LEU A 128
ILE A 137
LEU A 180
 None
 1.15A 4q0dB-4nsxA:
undetectable		 4q0dB-4nsxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  93
LEU A 112
LEU A 128
ILE A 137
LEU A 180
 None
 1.15A 4q0dE-4nsxA:
undetectable		 4q0dE-4nsxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 SER A 519
TYR A 529
ASP A 523
 None
 0.82A 4rp8C-4nsxA:
undetectable		 4rp8C-4nsxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 348
SER A 386
PHE A 378
SER A 368
HIS A 349
 None
 1.47A 4wryA-4nsxA:
undetectable		 4wryA-4nsxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 348
SER A 386
PHE A 378
SER A 368
HIS A 349
 None
 1.46A 4wrzA-4nsxA:
undetectable		 4wrzA-4nsxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 348
SER A 386
PHE A 378
SER A 368
HIS A 349
 None
 1.45A 4ws1A-4nsxA:
undetectable		 4ws1A-4nsxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 359
THR A 644
ALA A 642
LYS A 633
ILE A 653
 None
 1.14A 4x1yB-4nsxA:
undetectable		 4x1yB-4nsxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 300
VAL A  51
PHE A  58
VAL A 118
LEU A 121
 None
 1.00A 5ergB-4nsxA:
undetectable		 5ergB-4nsxA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 435
ASP A 436
ARG A 373
 None
 0.85A 5jwaA-4nsxA:
undetectable
5jwaH-4nsxA:
undetectable		 5jwaA-4nsxA:
21.26
5jwaH-4nsxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 482
ASP A 523
LEU A 560
GLY A 527
ILE A 525
 None
 1.18A 5vopB-4nsxA:
undetectable		 5vopB-4nsxA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 609
SER A 594
PHE A  24
GLY A 622
THR A 643
 None
 1.27A 6awpA-4nsxA:
undetectable		 6awpA-4nsxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  56
SER A 682
SER A 680
 None
 1.07A 6gbfA-4nsxA:
undetectable		 6gbfA-4nsxA:
22.35