SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		4 / 8 PHE A  36
PHE A  17
SER A  44
ALA A  16
 None
 0.93A 1rqpC-4nt1A:
undetectable		 1rqpC-4nt1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		4 / 8 PHE A  36
PHE A  17
SER A  44
ALA A  16
 None
 0.90A 1rqpA-4nt1A:
undetectable		 1rqpA-4nt1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		3 / 3 LEU A 158
PRO A 159
LEU A 127
 None
 0.57A 2po7B-4nt1A:
undetectable		 2po7B-4nt1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		3 / 3 LEU A 158
PRO A 159
LEU A 127
 None
 0.38A 2qd5B-4nt1A:
undetectable		 2qd5B-4nt1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		4 / 8 PHE A  36
PHE A  17
SER A  44
ALA A  16
 None
 0.89A 2v7uA-4nt1A:
undetectable		 2v7uA-4nt1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		3 / 3 LYS A   8
PRO A   9
LEU A  10
 None
 0.45A 3tpxE-4nt1A:
undetectable		 3tpxE-4nt1A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		3 / 3 LEU A 158
PRO A 159
LEU A 127
 None
 0.30A 3w1wB-4nt1A:
undetectable		 3w1wB-4nt1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		3 / 3 LYS A 169
LYS A   7
PRO A   9
 None
 1.01A 4dv1L-4nt1A:
undetectable		 4dv1L-4nt1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4nt1 ACCELERATED-CELL-DEA
TH 11
(Arabidopsis
thaliana) 		4 / 6 SER A  37
ARG A  70
ALA A  71
ALA A  63
 None
None
None
KCX  A  64 ( 3.2A)
 1.13A 6ma6A-4nt1A:
undetectable		 6ma6A-4nt1A:
19.46