SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 8 ILE A  71
MET A  38
ASN A  62
GLY A  60
 None
 0.92A 1dzmA-4nt4A:
undetectable		 1dzmA-4nt4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		5 / 10 GLU A 289
LEU A 314
ARG A 321
HIS A 154
LEU A 153
 None
 1.37A 1qkuA-4nt4A:
undetectable		 1qkuA-4nt4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		5 / 10 GLU A 289
LEU A 314
ARG A 321
HIS A 154
LEU A 153
 None
 1.37A 1qkuB-4nt4A:
undetectable		 1qkuB-4nt4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		5 / 10 GLU A 289
LEU A 314
ARG A 321
HIS A 154
LEU A 153
 None
 1.37A 1qkuC-4nt4A:
undetectable		 1qkuC-4nt4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 8 PRO A 254
THR A 277
PRO A 278
VAL A 281
 None
 0.96A 2v41C-4nt4A:
undetectable
2v41D-4nt4A:
undetectable		 2v41C-4nt4A:
22.54
2v41D-4nt4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 8 PRO A 254
THR A 277
PRO A 278
VAL A 281
 None
 1.02A 2v41C-4nt4A:
undetectable
2v41D-4nt4A:
undetectable		 2v41C-4nt4A:
22.54
2v41D-4nt4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 8 PRO A 254
THR A 277
PRO A 278
VAL A 281
 None
 0.96A 2v41G-4nt4A:
undetectable
2v41H-4nt4A:
undetectable		 2v41G-4nt4A:
22.54
2v41H-4nt4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 6 PHE A 302
ASP A 301
LYS A 213
GLU A 211
 None
SO4  A 402 (-2.9A)
None
None
 1.16A 2vn1B-4nt4A:
undetectable		 2vn1B-4nt4A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 6 TYR A  90
PRO A 101
ILE A 186
LEU A 125
 None
 1.21A 2wekB-4nt4A:
undetectable		 2wekB-4nt4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		5 / 12 ILE A 135
ASN A 134
TRP A 332
PHE A 140
PHE A 248
 None
 1.29A 3rzeA-4nt4A:
undetectable		 3rzeA-4nt4A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		5 / 12 PHE A 192
ASP A 237
GLY A 193
ALA A 195
SER A 214
 None
 1.10A 3sudB-4nt4A:
undetectable		 3sudB-4nt4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 5 LEU A 300
ARG A 298
ILE A 279
ARG A 295
 None
 1.23A 3ticA-4nt4A:
undetectable		 3ticA-4nt4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		5 / 12 GLU A  74
ILE A  71
ALA A  70
VAL A  69
PHE A  43
 None
 1.01A 4u8yB-4nt4A:
undetectable		 4u8yB-4nt4A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		5 / 12 GLU A  74
ILE A  71
ALA A  70
VAL A  69
PHE A  43
 None
 1.04A 4u95B-4nt4A:
undetectable		 4u95B-4nt4A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 5 ARG A 298
LEU A 294
PHE A 290
LEU A 282
 None
 1.19A 5iy5P-4nt4A:
2.4
5iy5W-4nt4A:
undetectable		 5iy5P-4nt4A:
22.15
5iy5W-4nt4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 5 ARG A 298
LEU A 294
PHE A 290
LEU A 282
 None
 1.13A 5x1fC-4nt4A:
2.5
5x1fJ-4nt4A:
undetectable		 5x1fC-4nt4A:
22.09
5x1fJ-4nt4A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 5 ARG A 298
LEU A 294
PHE A 290
LEU A 282
 None
 1.13A 5xdxC-4nt4A:
2.6
5xdxJ-4nt4A:
undetectable		 5xdxC-4nt4A:
22.15
5xdxJ-4nt4A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4nt4 GILGAMESH, ISOFORM I
(Drosophila
melanogaster) 		4 / 5 ARG A 298
LEU A 294
PHE A 290
LEU A 282
 None
 1.18A 5xdxP-4nt4A:
2.4
5xdxW-4nt4A:
undetectable		 5xdxP-4nt4A:
22.15
5xdxW-4nt4A:
14.68