SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ntb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 4ntb LEUKOTRIENE C4
SYNTHASE
(Mus
musculus) 		4 / 6 ILE A  27
ARG A  30
PHE A  46
PHE A  94
 None
 1.40A 1e73M-4ntbA:
undetectable		 1e73M-4ntbA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ntb LEUKOTRIENE C4
SYNTHASE
(Mus
musculus) 		4 / 8 THR A  66
CYH A  82
LEU A 117
MET A 121
 None
 1.41A 1uw6D-4ntbA:
undetectable
1uw6E-4ntbA:
undetectable		 1uw6D-4ntbA:
18.48
1uw6E-4ntbA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ntb LEUKOTRIENE C4
SYNTHASE
(Mus
musculus) 		4 / 8 THR A  66
CYH A  82
LEU A 117
MET A 121
 None
 1.39A 1uw6G-4ntbA:
undetectable
1uw6H-4ntbA:
undetectable		 1uw6G-4ntbA:
18.48
1uw6H-4ntbA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4ntb LEUKOTRIENE C4
SYNTHASE
(Mus
musculus) 		4 / 6 LEU A  84
LEU A  18
VAL A  14
PHE A  88
 None
PLM  A 206 (-4.0A)
None
None
 1.23A 4uswA-4ntbA:
undetectable		 4uswA-4ntbA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4ntb LEUKOTRIENE C4
SYNTHASE
(Mus
musculus) 		5 / 12 LEU A  81
ALA A  79
LEU A   8
LEU A   7
LEU A 118
 None
 1.08A 4zn7A-4ntbA:
undetectable		 4zn7A-4ntbA:
20.08