SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ntc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 10 LEU A 146
VAL A 161
VAL A 159
TYR A 143
GLY A 160
 None
 1.43A 1lw0A-4ntcA:
undetectable		 1lw0A-4ntcA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 9 LEU A 146
VAL A 161
VAL A 159
TYR A 143
GLY A 160
 None
 1.43A 1lwfA-4ntcA:
2.0		 1lwfA-4ntcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 12 ALA A  39
ASP A  15
VAL A 119
GLY A  31
ILE A  18
 None
 0.89A 1rl8A-4ntcA:
undetectable		 1rl8A-4ntcA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4ntc GLIT
(Aspergillus
fumigatus) 		4 / 7 ASP A  43
ALA A  21
GLY A 123
THR A  90
 FAD  A 401 (-3.2A)
FAD  A 401 (-4.1A)
FAD  A 401 (-3.5A)
FAD  A 401 (-4.2A)
 0.80A 1t7iB-4ntcA:
undetectable		 1t7iB-4ntcA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4ntc GLIT
(Aspergillus
fumigatus) 		4 / 7 ASP A  43
ALA A  21
GLY A 123
THR A  90
 FAD  A 401 (-3.2A)
FAD  A 401 (-4.1A)
FAD  A 401 (-3.5A)
FAD  A 401 (-4.2A)
 0.84A 1t7jB-4ntcA:
undetectable		 1t7jB-4ntcA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 10 ALA A 291
PHE A 290
LEU A 316
GLY A 115
PHE A 103
 None
 1.44A 1uhoA-4ntcA:
undetectable		 1uhoA-4ntcA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 10 TYR A  81
ARG A  80
GLY A  31
THR A  30
ALA A  33
 None
 1.35A 2coiA-4ntcA:
undetectable
2coiB-4ntcA:
undetectable		 2coiA-4ntcA:
21.77
2coiB-4ntcA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 10 TYR A  81
ARG A  80
GLY A  31
THR A  30
ALA A  33
 None
 1.33A 2coiA-4ntcA:
undetectable
2coiB-4ntcA:
undetectable		 2coiA-4ntcA:
21.77
2coiB-4ntcA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 9 TYR A  81
ARG A  80
GLY A  31
THR A  30
ALA A  33
 None
 1.26A 2cojA-4ntcA:
undetectable
2cojB-4ntcA:
undetectable		 2cojA-4ntcA:
21.77
2cojB-4ntcA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 10 LEU A 146
VAL A 161
VAL A 159
TYR A 143
GLY A 160
 None
 1.44A 2hnyA-4ntcA:
undetectable		 2hnyA-4ntcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 12 ALA A  39
ASP A  15
VAL A 119
GLY A  31
ILE A  18
 None
 0.86A 2o4kB-4ntcA:
undetectable		 2o4kB-4ntcA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 9 ALA A  39
ASP A  15
VAL A 119
GLY A  31
ILE A  18
 None
 1.04A 2q5kA-4ntcA:
undetectable		 2q5kA-4ntcA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 12 GLY A 309
GLY A  20
GLY A  22
SER A  27
THR A  90
 None
FAD  A 401 (-3.3A)
FAD  A 401 (-3.2A)
None
FAD  A 401 (-4.2A)
 0.85A 2wa2A-4ntcA:
undetectable		 2wa2A-4ntcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4ntc GLIT
(Aspergillus
fumigatus) 		4 / 6 ALA A  72
ALA A  75
THR A  78
PHE A  86
 None
 1.04A 2xfhA-4ntcA:
undetectable		 2xfhA-4ntcA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 12 ILE A 275
GLY A 123
ALA A 296
VAL A  46
PHE A  42
 None
FAD  A 401 (-3.5A)
None
FAD  A 401 (-4.3A)
None
 1.15A 2yvlD-4ntcA:
4.6		 2yvlD-4ntcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 12 LEU A 176
ALA A 180
LEU A 249
LEU A 164
ALA A 173
 None
 1.01A 3dfrA-4ntcA:
undetectable		 3dfrA-4ntcA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 10 LEU A 146
VAL A 161
VAL A 159
TYR A 143
GLY A 160
 None
 1.45A 3lp1A-4ntcA:
undetectable		 3lp1A-4ntcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 11 VAL A  16
ALA A  39
THR A  28
ILE A  18
ARG A  80
 None
 1.36A 3n23A-4ntcA:
undetectable		 3n23A-4ntcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 11 LEU A 316
VAL A  16
ALA A  39
THR A  28
ARG A  80
 None
 1.42A 3n23C-4ntcA:
undetectable		 3n23C-4ntcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 4ntc GLIT
(Aspergillus
fumigatus) 		4 / 7 ILE A 275
LEU A 267
ALA A 291
VAL A 292
 None
 0.60A 4g77A-4ntcA:
undetectable		 4g77A-4ntcA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4ntc GLIT
(Aspergillus
fumigatus) 		4 / 6 SER A  27
ARG A  48
GLY A 123
THR A 255
 None
FAD  A 401 (-4.5A)
FAD  A 401 (-3.5A)
None
 1.11A 5btcA-4ntcA:
undetectable
5btcB-4ntcA:
undetectable
5btcC-4ntcA:
undetectable		 5btcA-4ntcA:
23.11
5btcB-4ntcA:
23.70
5btcC-4ntcA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4ntc GLIT
(Aspergillus
fumigatus) 		5 / 11 LEU A 146
VAL A 161
VAL A 159
TYR A 143
GLY A 160
 None
 1.43A 5hbmA-4ntcA:
undetectable		 5hbmA-4ntcA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4ntc GLIT
(Aspergillus
fumigatus) 		3 / 3 HIS A  56
HIS A  63
HIS A  54
 None
 0.81A 5oexA-4ntcA:
undetectable		 5oexA-4ntcA:
21.21