SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ntd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		4 / 8 PRO A  96
GLU A 304
ASP A  10
ARG A  33
 None
 0.93A 1dtlA-4ntdA:
undetectable		 1dtlA-4ntdA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 9 ALA A 166
GLY A 161
ALA A 162
LEU A 185
LEU A 193
 None
 1.15A 1nr6A-4ntdA:
undetectable		 1nr6A-4ntdA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 12 PHE A 179
HIS A 181
ILE A 201
THR A 204
ALA A 221
 None
 1.31A 2gl0D-4ntdA:
undetectable
2gl0E-4ntdA:
undetectable		 2gl0D-4ntdA:
18.37
2gl0E-4ntdA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 11 PHE A 179
HIS A 181
ILE A 201
THR A 204
ALA A 221
 None
 1.34A 2gl0E-4ntdA:
undetectable
2gl0F-4ntdA:
undetectable		 2gl0E-4ntdA:
18.37
2gl0F-4ntdA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 11 LEU A 215
SER A 229
LEU A 153
VAL A 148
VAL A 233
 None
 1.35A 2po5B-4ntdA:
2.3		 2po5B-4ntdA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 9 HIS A 165
LEU A 169
LEU A 153
LEU A 137
HIS A 144
 CL  A 404 ( 3.9A)
None
None
None
GOL  A 403 ( 4.2A)
 1.41A 3q1eB-4ntdA:
undetectable
3q1eD-4ntdA:
undetectable		 3q1eB-4ntdA:
18.42
3q1eD-4ntdA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 12 ASN A 275
GLY A  17
SER A 286
GLY A 118
ASN A  22
 FAD  A 402 ( 3.7A)
FAD  A 402 (-3.5A)
FAD  A 402 (-3.4A)
FAD  A 402 ( 3.7A)
None
 1.31A 3r24A-4ntdA:
undetectable		 3r24A-4ntdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		4 / 8 ALA A  30
ASN A 298
PHE A 295
ALA A 294
 None
 1.08A 3t3sE-4ntdA:
undetectable		 3t3sE-4ntdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		4 / 8 ALA A  30
ASN A 298
PHE A 295
ALA A 294
 None
 0.94A 3t3sF-4ntdA:
undetectable		 3t3sF-4ntdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 12 PHE A  79
LEU A  25
GLY A  17
GLY A  20
VAL A  13
 None
None
FAD  A 402 (-3.5A)
None
None
 1.12A 4a6eA-4ntdA:
undetectable		 4a6eA-4ntdA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 12 VAL A 176
LEU A 178
ALA A 162
LEU A 168
LEU A 169
 None
None
None
CL  A 404 ( 4.7A)
None
 1.20A 4i1rA-4ntdA:
2.4		 4i1rA-4ntdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 11 SER A 286
GLY A 274
LEU A 119
GLY A 118
LEU A 208
 FAD  A 402 (-3.4A)
FAD  A 402 (-3.3A)
None
FAD  A 402 ( 3.7A)
None
 0.99A 4kt0A-4ntdA:
undetectable
4kt0J-4ntdA:
undetectable		 4kt0A-4ntdA:
18.36
4kt0J-4ntdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 11 PHE A  53
GLY A  58
ALA A  63
LEU A  64
ALA A  28
 None
 1.13A 4l6v1-4ntdA:
undetectable
4l6v6-4ntdA:
undetectable		 4l6v1-4ntdA:
18.36
4l6v6-4ntdA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		3 / 3 SER A 229
ALA A 227
VAL A 226
 None
 0.51A 4o2bA-4ntdA:
undetectable		 4o2bA-4ntdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 12 GLY A  17
ALA A  18
GLY A  20
GLY A  19
LEU A  25
 FAD  A 402 (-3.5A)
FAD  A 402 (-4.7A)
None
FAD  A 402 (-3.7A)
None
 0.84A 4o33A-4ntdA:
2.8		 4o33A-4ntdA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		4 / 5 ARG A 311
ARG A  97
GLY A  91
GLU A  90
 None
 0.99A 4z3oA-4ntdA:
undetectable
4z3oB-4ntdA:
undetectable		 4z3oA-4ntdA:
19.03
4z3oB-4ntdA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 10 ALA A 296
ARG A 112
ALA A 293
VAL A 114
LEU A 301
 None
 1.46A 5eb5B-4ntdA:
12.7		 5eb5B-4ntdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		4 / 6 ILE A 257
ALA A 246
THR A 245
VAL A 115
 None
 0.92A 5eclD-4ntdA:
undetectable		 5eclD-4ntdA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		3 / 3 VAL A 205
ARG A 170
PRO A 199
 None
 0.79A 5koxA-4ntdA:
8.6		 5koxA-4ntdA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		5 / 9 LEU A 178
PRO A 199
GLY A 154
LEU A 193
ALA A 166
 None
 0.96A 5o96A-4ntdA:
3.1
5o96B-4ntdA:
3.1		 5o96A-4ntdA:
21.07
5o96B-4ntdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		3 / 3 THR A  99
ALA A 107
LYS A   1
 None
 0.64A 6fgcA-4ntdA:
undetectable		 6fgcA-4ntdA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4ntd THIOREDOXIN
REDUCTASE
(Streptomyces
clavuligerus) 		3 / 3 THR A  99
ALA A 107
LYS A   1
 None
 0.62A 6fgdA-4ntdA:
5.1		 6fgdA-4ntdA:
24.07