SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ntj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ASN A 290
PHE A  59
LEU A 301
TYR A 209
PHE A  50
 None
 1.28A 1pj7A-4ntjA:
undetectable		 1pj7A-4ntjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12
(Escherichia
coli;
Homo
sapiens) 		4 / 5 LEU A 293
PHE A  77
MET A  73
SER A  69
 None
 1.15A 1wrlC-4ntjA:
undetectable		 1wrlC-4ntjA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASP A1073
LEU A1076
LYS A1077
ARG A1034
 None
 1.33A 2gj5A-4ntjA:
undetectable		 2gj5A-4ntjA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ILE A  61
SER A  55
ILE A  68
PHE A 114
 None
 1.10A 2q72A-4ntjA:
undetectable		 2q72A-4ntjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12
(Escherichia
coli;
Homo
sapiens) 		6 / 12 PHE A 305
ALA A  46
ASN A 294
ILE A  61
ASN A  65
THR A  66
 None
 1.34A 2rlcA-4ntjA:
undetectable		 2rlcA-4ntjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A1036
ALA A1035
ALA A1040
VAL A1016
ILE A1017
 None
 1.12A 3falA-4ntjA:
undetectable		 3falA-4ntjA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12
(Escherichia
coli;
Homo
sapiens) 		4 / 8 SER A 180
PHE A 182
LEU A 157
PRO A 158
 None
 1.22A 3jq7B-4ntjA:
undetectable		 3jq7B-4ntjA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12
(Escherichia
coli;
Homo
sapiens) 		4 / 5 PHE A  77
PHE A  37
LEU A  40
LEU A  82
 None
 1.35A 5veuH-4ntjA:
0.0		 5veuH-4ntjA:
22.08