SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ntl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		3 / 3 ASN A  69
ALA A  86
ASN A  84
 None
 0.66A 1n4fA-4ntlA:
undetectable		 1n4fA-4ntlA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 12 ILE A 177
ALA A 131
MET A 198
ILE A 217
PHE A 179
 None
 1.31A 1y0xX-4ntlA:
undetectable		 1y0xX-4ntlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 12 ALA A  83
LEU A 247
LEU A  47
LYS A  44
PHE A  85
 None
 1.20A 2oipB-4ntlA:
undetectable		 2oipB-4ntlA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		4 / 5 TYR A 110
PHE A  85
VAL A  38
TYR A 259
 None
 1.03A 2x7hA-4ntlA:
undetectable		 2x7hA-4ntlA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		4 / 5 TYR A 110
PHE A  85
VAL A  38
TYR A 259
 None
 1.03A 2x7hB-4ntlA:
undetectable		 2x7hB-4ntlA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 11 ALA A 151
ILE A 148
ILE A 135
PRO A 136
ILE A 155
 None
 1.02A 3clbA-4ntlA:
undetectable		 3clbA-4ntlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 12 ALA A 151
ILE A 148
ILE A 135
PRO A 136
ILE A 155
 None
 1.00A 3clbC-4ntlA:
undetectable		 3clbC-4ntlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 10 ALA A 151
ILE A 148
ILE A 135
PRO A 136
ILE A 155
 None
 0.93A 3clbD-4ntlA:
undetectable		 3clbD-4ntlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 10 ALA A 151
ILE A 148
ILE A 135
PRO A 136
ILE A 155
 None
 1.03A 3hbbA-4ntlA:
undetectable		 3hbbA-4ntlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 11 ALA A 151
ILE A 148
ILE A 135
PRO A 136
ILE A 155
 None
 0.92A 3hbbC-4ntlA:
undetectable		 3hbbC-4ntlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 10 ALA A 151
ILE A 148
ILE A 135
PRO A 136
ILE A 155
 None
 0.89A 3hbbD-4ntlA:
undetectable		 3hbbD-4ntlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 11 TYR A 228
HIS A  88
LEU A 184
PHE A 112
PHE A 200
 None
EDO  A 307 (-3.1A)
None
None
None
 1.30A 3jwqA-4ntlA:
undetectable
3jwqD-4ntlA:
undetectable		 3jwqA-4ntlA:
22.41
3jwqD-4ntlA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		4 / 7 TYR A 228
ILE A 135
HIS A  88
LEU A 184
 None
None
EDO  A 307 (-3.1A)
None
 1.04A 4l1wA-4ntlA:
undetectable		 4l1wA-4ntlA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A 206
PRO A 136
LEU A 149
PHE A 116
ILE A 148
 None
 1.48A 5dv4A-4ntlA:
undetectable		 5dv4A-4ntlA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		4 / 6 ALA A 250
THR A 252
VAL A 256
VAL A 232
 None
 0.92A 5eckA-4ntlA:
undetectable		 5eckA-4ntlA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 12 ASP A 221
GLU A 220
LEU A 157
ALA A 147
ARG A 144
 None
 1.25A 5nd4B-4ntlA:
undetectable		 5nd4B-4ntlA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 4ntl LIPOPROTEIN, YAEC
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 143
GLY A 134
LYS A 132
ASP A 195
ILE A 182
 None
None
None
NA  A 311 (-2.6A)
None
 1.00A 5wz1E-4ntlA:
undetectable		 5wz1E-4ntlA:
18.79