SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 11 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.90A 1hxwB-4nu2A:
undetectable		 1hxwB-4nu2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 9 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.93A 1ohrB-4nu2A:
undetectable		 1ohrB-4nu2A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		4 / 7 LEU A 212
ILE A 186
ALA A 218
ILE A 241
 None
 0.98A 1oniB-4nu2A:
undetectable
1oniC-4nu2A:
undetectable		 1oniB-4nu2A:
20.97
1oniC-4nu2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 12 LEU A 212
ASN A 256
ILE A 255
MET A 204
SER A 235
 None
 1.47A 1xotB-4nu2A:
undetectable		 1xotB-4nu2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 12 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.96A 2ieoA-4nu2A:
undetectable		 2ieoA-4nu2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 9 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.95A 2o4pB-4nu2A:
undetectable		 2o4pB-4nu2A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		4 / 7 LEU A  67
LEU A  64
ILE A 195
ARG A 149
 None
 1.07A 2qqcA-4nu2A:
undetectable
2qqcF-4nu2A:
undetectable		 2qqcA-4nu2A:
18.24
2qqcF-4nu2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		4 / 7 LEU A  67
LEU A  64
ILE A 195
ARG A 149
 None
 1.07A 2qqcG-4nu2A:
undetectable
2qqcJ-4nu2A:
undetectable		 2qqcG-4nu2A:
18.24
2qqcJ-4nu2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		4 / 7 LEU A  67
LEU A  64
ILE A 195
ARG A 149
 None
 1.07A 2qqcI-4nu2A:
undetectable
2qqcL-4nu2A:
undetectable		 2qqcI-4nu2A:
18.24
2qqcL-4nu2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		4 / 7 LEU A  67
LEU A  64
ILE A 195
ARG A 149
 None
 1.05A 2qqdA-4nu2A:
undetectable
2qqdE-4nu2A:
undetectable		 2qqdA-4nu2A:
18.24
2qqdE-4nu2A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 9 ALA A 261
ALA A  95
GLY A  94
GLY A  80
ILE A  98
 None
 1.23A 2v7bA-4nu2A:
undetectable		 2v7bA-4nu2A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 9 ALA A 261
ALA A  95
GLY A  94
GLY A  80
ILE A  98
 None
 1.25A 2v7bB-4nu2A:
undetectable		 2v7bB-4nu2A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		4 / 7 ILE A 195
ILE A 180
LEU A  62
LEU A 212
 None
 0.94A 3adxA-4nu2A:
undetectable		 3adxA-4nu2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 9 ALA A 101
ILE A  98
ASP A 118
SER A  77
ILE A 114
 None
 1.31A 3hbbB-4nu2A:
undetectable		 3hbbB-4nu2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		3 / 3 ARG A 258
THR A  79
THR A 225
 None
 0.71A 3k2hB-4nu2A:
undetectable		 3k2hB-4nu2A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 10 LEU A 178
VAL A 229
GLY A 239
ILE A 221
LEU A 202
 None
 0.82A 3ogqA-4nu2A:
undetectable		 3ogqA-4nu2A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 11 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.88A 3oy4A-4nu2A:
undetectable		 3oy4A-4nu2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 11 ILE A 247
ALA A 228
ILE A 180
LEU A 231
THR A 245
 None
 1.15A 3qg2B-4nu2A:
undetectable		 3qg2B-4nu2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		4 / 7 ILE A 241
SER A  77
LEU A 267
VAL A 265
 None
 0.68A 3ua5B-4nu2A:
undetectable		 3ua5B-4nu2A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 12 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.95A 4dqfA-4nu2A:
undetectable		 4dqfA-4nu2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 11 LEU A 202
VAL A 198
MET A 204
LYS A 165
ILE A 184
 None
 1.45A 4pghC-4nu2A:
undetectable		 4pghC-4nu2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 11 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.96A 4qgiB-4nu2A:
undetectable		 4qgiB-4nu2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 11 ASP A  92
LEU A 132
LYS A  78
ILE A  81
ILE A  89
 None
 1.18A 5gpgA-4nu2A:
undetectable		 5gpgA-4nu2A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 9 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.94A 5kr0B-4nu2A:
undetectable		 5kr0B-4nu2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4nu2 ANTIFREEZE PROTEIN
(Flavobacterium
frigoris) 		5 / 12 LEU A 178
VAL A 229
GLY A 239
ILE A 221
VAL A 198
 None
 0.92A 6dilA-4nu2A:
undetectable		 6dilA-4nu2A:
15.56