SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 11 LEU A 158
VAL A 209
GLY A 219
ILE A 201
VAL A 178
 None
 0.92A 1hxwB-4nu3A:
undetectable		 1hxwB-4nu3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 9 LEU A 158
VAL A 209
GLY A 219
ILE A 201
VAL A 178
 None
 0.94A 1ohrB-4nu3A:
undetectable		 1ohrB-4nu3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		4 / 7 LEU A 192
ILE A 166
ALA A 198
ILE A 221
 None
 0.93A 1oniB-4nu3A:
undetectable
1oniC-4nu3A:
undetectable		 1oniB-4nu3A:
20.00
1oniC-4nu3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		4 / 4 TRP A 174
SER A  50
LYS A  51
VAL A 116
 None
 1.36A 1qu3A-4nu3A:
0.0		 1qu3A-4nu3A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 12 ILE A  48
VAL A 116
MET A 119
ALA A 244
THR A 246
 None
 1.07A 1r9oA-4nu3A:
undetectable		 1r9oA-4nu3A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		4 / 7 GLU A 218
TRP A 174
LYS A 199
GLY A 219
 None
 1.29A 2hs1B-4nu3A:
undetectable		 2hs1B-4nu3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 9 LEU A 158
VAL A 209
GLY A 219
ILE A 201
VAL A 178
 None
 0.97A 2o4pB-4nu3A:
undetectable		 2o4pB-4nu3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 12 PRO A 109
THR A 108
LEU A 112
ILE A  99
VAL A 245
 None
 1.29A 3a51B-4nu3A:
undetectable		 3a51B-4nu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		3 / 3 ARG A 238
THR A  52
THR A 205
 None
 0.73A 3k2hB-4nu3A:
undetectable		 3k2hB-4nu3A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 10 LEU A 158
VAL A 209
GLY A 219
ILE A 201
LEU A 182
 None
 0.84A 3ogqA-4nu3A:
undetectable		 3ogqA-4nu3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 11 LEU A 158
VAL A 209
GLY A 219
ILE A 201
VAL A 178
 None
 0.91A 3oy4A-4nu3A:
undetectable		 3oy4A-4nu3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 11 ILE A 227
ALA A 208
ILE A 160
LEU A 211
THR A 225
 None
 1.17A 3qg2B-4nu3A:
undetectable		 3qg2B-4nu3A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		3 / 3 PHE A  79
SER A  92
GLN A  94
 None
 1.00A 3smtA-4nu3A:
undetectable		 3smtA-4nu3A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		4 / 7 ILE A 221
SER A  50
LEU A 247
VAL A 245
 None
 0.63A 3ua5B-4nu3A:
undetectable		 3ua5B-4nu3A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 12 ALA A 198
GLU A 218
ILE A 190
PHE A 217
LEU A 182
 None
 1.13A 4cd2A-4nu3A:
undetectable		 4cd2A-4nu3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 12 ILE A 166
ALA A 198
LEU A 211
VAL A 209
ILE A 190
 None
 1.10A 4m2xG-4nu3A:
undetectable		 4m2xG-4nu3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		4 / 7 ILE A  54
PHE A  79
LEU A 247
THR A 253
 None
 0.98A 4mmcA-4nu3A:
undetectable		 4mmcA-4nu3A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 12 GLY A 168
SER A 169
GLY A 195
LEU A 192
LEU A 147
 None
 0.94A 5c0oH-4nu3A:
undetectable		 5c0oH-4nu3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 11 ASP A  65
LEU A 112
LYS A  51
ILE A  54
ILE A  62
 None
 1.18A 5gpgA-4nu3A:
undetectable		 5gpgA-4nu3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 9 LEU A 158
VAL A 209
GLY A 219
ILE A 201
VAL A 178
 None
 0.95A 5kr0B-4nu3A:
undetectable		 5kr0B-4nu3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4nu3 ICE-BINDING PROTEIN
(Flavobacterium
frigoris) 		5 / 12 LEU A 158
VAL A 209
GLY A 219
ILE A 201
VAL A 178
 None
 0.93A 6dilA-4nu3A:
undetectable		 6dilA-4nu3A:
13.33