SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nu7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		4 / 8 GLU A  97
LEU A 133
ALA A 136
LEU A 137
 None
 0.68A 1hwiB-4nu7A:
undetectable		 1hwiB-4nu7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		4 / 8 GLU A  97
LEU A 133
ALA A 136
LEU A 137
 None
 0.64A 1hwiD-4nu7A:
undetectable		 1hwiD-4nu7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		4 / 8 GLU A  97
LEU A 133
ALA A 136
LEU A 137
 None
 0.64A 1hwiC-4nu7A:
undetectable		 1hwiC-4nu7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		3 / 3 HIS A  71
MET A 148
MET A  73
 ZN  A 303 (-3.2A)
None
None
 1.25A 2vj1A-4nu7A:
undetectable		 2vj1A-4nu7A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		4 / 6 ILE A  92
ILE A   8
LEU A  72
PHE A  94
 None
 0.83A 3adsA-4nu7A:
undetectable		 3adsA-4nu7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		4 / 7 ILE A  92
ILE A   8
LEU A  72
PHE A  94
 None
 0.85A 3adxA-4nu7A:
undetectable		 3adxA-4nu7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		4 / 8 PRO A  83
ALA A  85
ALA A  89
ILE A  81
 None
None
None
CL  A 302 ( 4.9A)
 0.83A 3dtuC-4nu7A:
undetectable
3dtuD-4nu7A:
undetectable		 3dtuC-4nu7A:
18.01
3dtuD-4nu7A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		3 / 3 HIS A  71
HIS A  95
MET A  73
 ZN  A 303 (-3.2A)
None
None
 0.67A 3mihA-4nu7A:
undetectable		 3mihA-4nu7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		4 / 8 GLY A 155
GLY A 184
LEU A 185
VAL A 202
 SO4  A 304 (-3.3A)
SO4  A 304 (-3.8A)
None
None
 0.86A 4fgzB-4nu7A:
undetectable		 4fgzB-4nu7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		4 / 5 THR A 169
THR A 128
LEU A 122
LEU A 145
 None
 1.04A 4lvcB-4nu7A:
undetectable		 4lvcB-4nu7A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE
(Toxoplasma
gondii) 		5 / 9 THR A 189
LEU A 164
GLN A   4
ASN A 199
LEU A 185
 None
 1.34A 5fhzB-4nu7A:
undetectable		 5fhzB-4nu7A:
17.79