SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4nux INTERLEUKIN-17
RECEPTOR A
(Homo
sapiens) 		4 / 5 PRO A 493
ALA A 494
ASP A 515
ASP A 489
 None
 1.21A 2nyuB-4nuxA:
undetectable		 2nyuB-4nuxA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4nux INTERLEUKIN-17
RECEPTOR A
(Homo
sapiens) 		3 / 3 PHE A 504
TYR A 384
TYR A 391
 None
 1.06A 4ffwA-4nuxA:
2.5		 4ffwA-4nuxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4nux INTERLEUKIN-17
RECEPTOR A
(Homo
sapiens) 		5 / 12 PHE A 574
SER A 448
LEU A 446
GLU A 417
ASP A 413
 None
 1.31A 4qb9E-4nuxA:
undetectable		 4qb9E-4nuxA:
18.22