SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 6 ASN A 677
PHE A 666
GLY A 645
TYR A 644
 None
 1.09A 1c8lA-4nuzA:
undetectable		 1c8lA-4nuzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 10 LEU A 518
LEU A 565
ILE A 618
PHE A 573
ILE A 594
 None
 1.39A 1i18A-4nuzA:
undetectable
1i18B-4nuzA:
undetectable		 1i18A-4nuzA:
7.79
1i18B-4nuzA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 10 PHE A 573
ILE A 594
LEU A 518
LEU A 565
ILE A 618
 None
 1.42A 1i18A-4nuzA:
undetectable
1i18B-4nuzA:
undetectable		 1i18A-4nuzA:
7.79
1i18B-4nuzA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 11 ASN A 677
PHE A 666
TYR A 640
GLY A 645
TYR A 644
 None
 1.49A 1l5rA-4nuzA:
undetectable		 1l5rA-4nuzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 7 GLN A 330
GLU A 326
MET A 283
ALA A 284
 None
 1.31A 1linA-4nuzA:
undetectable		 1linA-4nuzA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 11 LEU A 518
VAL A 467
LEU A 463
LEU A 557
LEU A 523
 None
 1.21A 1mx1B-4nuzA:
undetectable		 1mx1B-4nuzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_2
(GLUCOCORTICOID
RECEPTOR)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 4 TRP A 388
MET A 325
PHE A 400
TYR A 332
 None
 1.46A 1nhzA-4nuzA:
0.0		 1nhzA-4nuzA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 12 LEU A 586
LEU A 562
LEU A 568
ILE A 610
ILE A 510
 None
 1.24A 1tw4B-4nuzA:
undetectable		 1tw4B-4nuzA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		3 / 3 GLY A 408
ASP A 407
ASN A 374
 None
 0.57A 1vq1A-4nuzA:
2.3		 1vq1A-4nuzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 ALA A 684
TYR A 685
ALA A 680
TYR A 682
 None
 0.99A 1xl6A-4nuzA:
2.3
1xl6B-4nuzA:
2.5		 1xl6A-4nuzA:
15.25
1xl6B-4nuzA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 8 PHE A 400
ASP A 231
TYR A 117
LEU A 300
 None
 0.87A 2bfpA-4nuzA:
3.1		 2bfpA-4nuzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 8 PHE A 400
ASP A 231
TYR A 117
LEU A 300
 None
 0.87A 2bfpD-4nuzA:
undetectable		 2bfpD-4nuzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 8 SER A 887
PHE A 825
ALA A 829
LEU A 792
 None
 1.15A 2bxkA-4nuzA:
4.0		 2bxkA-4nuzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 12 LEU A 230
ARG A 181
ILE A 180
PHE A 148
GLY A 266
 None
 0.96A 2lbdA-4nuzA:
undetectable		 2lbdA-4nuzA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		3 / 3 SER A 708
HIS A 701
ASP A 697
 None
 0.67A 2wa2B-4nuzA:
undetectable		 2wa2B-4nuzA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 4 ALA A 684
TYR A 685
ALA A 680
TYR A 682
 None
 1.00A 2wlkA-4nuzA:
2.6
2wlkB-4nuzA:
2.4		 2wlkA-4nuzA:
15.25
2wlkB-4nuzA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 11 TYR A 223
ILE A 217
LEU A 264
VAL A 222
ILE A 180
 None
 1.14A 3b2rB-4nuzA:
undetectable		 3b2rB-4nuzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 ASN A 677
PHE A 666
GLY A 645
TYR A 644
 None
 1.12A 3bcrA-4nuzA:
2.0		 3bcrA-4nuzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 HIS A 236
ASP A 237
PRO A 240
LYS A 241
 None
 1.36A 3h1xA-4nuzA:
undetectable		 3h1xA-4nuzA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 12 VAL A 436
GLY A 408
VAL A 409
HIS A 411
SER A 346
 None
 1.26A 4bvaA-4nuzA:
undetectable		 4bvaA-4nuzA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 ARG A 608
THR A 605
ASP A 600
TYR A 685
 None
 1.33A 4oltA-4nuzA:
undetectable		 4oltA-4nuzA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 ARG A 608
THR A 605
ASP A 600
TYR A 685
 None
 1.34A 4oltB-4nuzA:
undetectable		 4oltB-4nuzA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 6 ALA A 147
ASP A 228
LEU A 140
SER A 136
 None
 1.12A 4ot2A-4nuzA:
3.5		 4ot2A-4nuzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 GLN A 256
SER A 254
ASP A 247
ASP A 243
 None
 1.31A 4qtuB-4nuzA:
undetectable		 4qtuB-4nuzA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 GLN A 256
SER A 254
ASP A 247
ASP A 243
 None
 1.29A 4qtuD-4nuzA:
undetectable		 4qtuD-4nuzA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 ARG A 608
THR A 605
ASP A 600
TYR A 685
 None
 1.33A 4qwpA-4nuzA:
undetectable		 4qwpA-4nuzA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 5 ARG A 608
THR A 605
ASP A 600
TYR A 685
 None
 1.34A 4qwpB-4nuzA:
undetectable		 4qwpB-4nuzA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 7 LEU A 962
SER A 965
ILE A 976
VAL A 973
 None
 1.20A 4tvtA-4nuzA:
undetectable		 4tvtA-4nuzA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 11 ALA A 403
HIS A 151
THR A 182
ILE A 180
ASP A 231
 None
 1.36A 4uuuA-4nuzA:
undetectable
4uuuB-4nuzA:
undetectable		 4uuuA-4nuzA:
10.07
4uuuB-4nuzA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 11 ALA A 147
LEU A 146
LEU A 109
ARG A 274
LEU A 275
 None
 1.00A 4wg0E-4nuzA:
undetectable
4wg0F-4nuzA:
undetectable
4wg0G-4nuzA:
undetectable		 4wg0E-4nuzA:
1.46
4wg0F-4nuzA:
1.46
4wg0G-4nuzA:
1.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 11 ALA A 147
LEU A 146
LEU A 109
ARG A 274
LEU A 275
 None
 1.16A 4wg0I-4nuzA:
undetectable
4wg0J-4nuzA:
undetectable
4wg0K-4nuzA:
undetectable		 4wg0I-4nuzA:
1.46
4wg0J-4nuzA:
1.46
4wg0K-4nuzA:
1.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 12 GLY A 115
TYR A 450
VAL A 537
GLY A 344
LEU A 146
 None
 1.06A 5hg0A-4nuzA:
undetectable		 5hg0A-4nuzA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		5 / 12 GLY A 115
TYR A 450
VAL A 537
GLY A 344
LEU A 146
 None
 1.05A 5hg0B-4nuzA:
undetectable		 5hg0B-4nuzA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2
(Streptococcus
pyogenes) 		4 / 8 GLN A 879
TYR A 876
ILE A 839
ALA A 885
 None
 1.05A 6hu9a-4nuzA:
3.0
6hu9e-4nuzA:
undetectable		 6hu9a-4nuzA:
21.16
6hu9e-4nuzA:
9.94