SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		5 / 12 ILE A 265
ILE A  60
LEU A 160
LEU A 300
ILE A 241
 None
 0.99A 1df7A-4nv0A:
undetectable		 1df7A-4nv0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		5 / 11 GLY A 125
PHE A  75
ASN A  79
GLY A 208
PHE A  78
 None
MG7  A 403 (-3.6A)
MG7  A 403 ( 4.7A)
None
None
 1.27A 1ho5A-4nv0A:
undetectable		 1ho5A-4nv0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		5 / 10 GLY A 125
PHE A  75
ASN A  79
GLY A 208
PHE A  78
 None
MG7  A 403 (-3.6A)
MG7  A 403 ( 4.7A)
None
None
 1.19A 1ho5B-4nv0A:
undetectable		 1ho5B-4nv0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		4 / 4 ALA A 158
VAL A 187
PHE A 156
THR A 167
 None
 1.37A 2pkkA-4nv0A:
4.0		 2pkkA-4nv0A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		4 / 6 LEU A 206
SER A  74
PHE A  75
ASP A  57
 None
MG7  A 403 ( 4.2A)
MG7  A 403 (-3.6A)
MG7  A 403 (-3.9A)
 1.28A 2vn1B-4nv0A:
undetectable		 2vn1B-4nv0A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		3 / 3 GLY A 173
ASP A  57
SER A  73
 MG7  A 403 (-3.5A)
MG7  A 403 (-3.9A)
MG7  A 403 ( 4.6A)
 0.63A 3brfA-4nv0A:
undetectable		 3brfA-4nv0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		3 / 3 ARG A  64
ASP A 270
ASP A 289
 None
 0.89A 3jayA-4nv0A:
undetectable		 3jayA-4nv0A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		3 / 3 VAL A 242
VAL A 256
SER A 259
 None
 0.75A 3n8xB-4nv0A:
undetectable		 3n8xB-4nv0A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		4 / 6 THR A 167
ASN A 191
GLY A 164
ILE A 303
 None
 0.95A 3w9tF-4nv0A:
undetectable		 3w9tF-4nv0A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		4 / 6 SER A 171
GLU A 103
ASP A 270
ASP A  57
 MGF  A 404 (-2.7A)
MG7  A 403 (-2.8A)
None
MG7  A 403 (-3.9A)
 1.08A 4blvA-4nv0A:
2.4		 4blvA-4nv0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		3 / 3 ARG A  13
GLU A  36
ASN A  40
 PGE  A 401 (-2.8A)
PGE  A 401 (-3.9A)
PGE  A 401 (-3.8A)
 0.88A 4imaD-4nv0A:
undetectable		 4imaD-4nv0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		3 / 3 ARG A  13
GLU A  36
ASN A  40
 PGE  A 401 (-2.8A)
PGE  A 401 (-3.9A)
PGE  A 401 (-3.8A)
 0.84A 4ip7D-4nv0A:
undetectable		 4ip7D-4nv0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		5 / 12 ILE A 265
ILE A  60
LEU A 160
LEU A 300
ILE A 241
 None
 1.03A 4km2B-4nv0A:
undetectable		 4km2B-4nv0A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		5 / 12 ILE A 265
ILE A  60
LEU A 160
LEU A 300
ILE A 241
 None
 0.96A 4m2xA-4nv0A:
undetectable		 4m2xA-4nv0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		5 / 12 ILE A 265
ILE A  60
LEU A 160
LEU A 300
ILE A 241
 None
 0.98A 4m2xC-4nv0A:
undetectable		 4m2xC-4nv0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		5 / 12 ILE A 265
ILE A  60
LEU A 160
LEU A 300
ILE A 241
 None
 0.99A 4m2xE-4nv0A:
undetectable		 4m2xE-4nv0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		4 / 6 SER A 254
GLU A 221
GLY A 266
GLY A 244
 None
 0.96A 5cdpA-4nv0A:
undetectable
5cdpB-4nv0A:
undetectable		 5cdpA-4nv0A:
20.50
5cdpB-4nv0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE
(Drosophila
melanogaster) 		3 / 3 HIS A 261
HIS A 239
ARG A  49
 None
 0.99A 6b58A-4nv0A:
2.3		 6b58A-4nv0A:
21.14