SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nv1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 4 LYS C  65
LEU C  62
LEU C  82
SER C  85
 None
 1.47A 1tt6A-4nv1C:
undetectable		 1tt6A-4nv1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 6 LYS C  65
LEU C  62
LEU C  82
SER C  85
 None
 1.30A 1tyrA-4nv1C:
undetectable		 1tyrA-4nv1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 4 LYS C  65
LEU C  62
LEU C  82
SER C  85
 None
 1.20A 1tz8D-4nv1C:
undetectable		 1tz8D-4nv1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 6 VAL C  86
LEU C  82
PHE C  78
MET C  55
 None
 1.11A 1x8vA-4nv1C:
undetectable		 1x8vA-4nv1C:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		3 / 3 TYR C 149
GLU C 156
ASN C  90
 0FX  C 301 (-4.0A)
None
None
 0.99A 2y7hC-4nv1C:
undetectable		 2y7hC-4nv1C:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 6 THR C   8
LEU C  14
GLU C  44
SER C  37
 None
 1.25A 3b6rB-4nv1C:
undetectable		 3b6rB-4nv1C:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		5 / 12 ASN C  90
ASP C 123
ASP C 127
LEU C  77
ASN C  84
 None
 1.23A 3eeoA-4nv1C:
undetectable		 3eeoA-4nv1C:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 7 CYH C  72
PHE C  41
PHE C  17
TYR C  31
 None
 1.35A 3hggA-4nv1C:
undetectable		 3hggA-4nv1C:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		5 / 12 GLY C  22
SER C  23
ASN C  19
ASP C  16
VAL C   6
 None
 1.20A 4dx5B-4nv1C:
undetectable		 4dx5B-4nv1C:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 5 ILE C 224
ASP C 198
GLU C 194
VAL C 233
 None
 1.11A 4nkxC-4nv1C:
undetectable		 4nkxC-4nv1C:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 5 ILE C 224
ASP C 198
GLU C 194
VAL C 233
 None
 1.12A 4nkxD-4nv1C:
undetectable		 4nkxD-4nv1C:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 4 ASP C 127
GLY C  94
PRO C  93
GLN C 105
 None
None
None
0FX  C 301 (-3.1A)
 1.38A 4oltA-4nv1C:
undetectable		 4oltA-4nv1C:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 5 PHE C 146
SER C 145
GLN C 153
ASP C   9
 None
0FX  C 301 ( 4.2A)
None
None
 1.31A 5kpcA-4nv1C:
undetectable		 5kpcA-4nv1C:
19.00