SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		5 / 12 ALA A  35
LEU A  81
PHE A  80
LEU A 143
THR A  38
 None
 0.98A 1bzfA-4nv2A:
undetectable		 1bzfA-4nv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		4 / 5 LEU A  33
ALA A  35
LEU A  77
MET A 111
 None
None
None
U10  A 501 ( 4.6A)
 1.15A 2oaxA-4nv2A:
undetectable		 2oaxA-4nv2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		3 / 3 TYR A 207
GLY A 235
PRO A 236
 None
 0.73A 4qwpA-4nv2A:
undetectable		 4qwpA-4nv2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		5 / 11 GLY A  76
LEU A  77
LEU A 143
ALA A  27
SER A  31
 U10  A 501 (-3.6A)
None
None
None
None
 1.12A 4wnuA-4nv2A:
undetectable		 4wnuA-4nv2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		5 / 11 LEU A 107
GLY A  76
LEU A  77
ALA A  27
SER A  31
 None
U10  A 501 (-3.6A)
None
None
None
 1.21A 4wnuC-4nv2A:
undetectable		 4wnuC-4nv2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		5 / 9 LEU A 107
LEU A  84
GLY A  82
LEU A  23
ALA A  27
 None
 0.98A 5dqfA-4nv2A:
2.7		 5dqfA-4nv2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		4 / 6 THR A 174
VAL A 177
TYR A 178
VAL A  75
 None
 0.93A 5eckA-4nv2A:
undetectable		 5eckA-4nv2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		4 / 6 THR A 174
VAL A 177
TYR A 178
VAL A  75
 None
 0.91A 5eckD-4nv2A:
undetectable		 5eckD-4nv2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		4 / 6 THR A 174
VAL A 177
TYR A 178
VAL A  75
 None
 0.80A 5eclA-4nv2A:
undetectable		 5eclA-4nv2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN
(Synechococcus
sp.
JA-2-3B'a(2-13)) 		5 / 12 LEU A 143
GLY A  28
GLY A  30
LEU A  84
ALA A  87
 None
 0.89A 5l0zA-4nv2A:
undetectable		 5l0zA-4nv2A:
23.65