SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 HIS A  90
PHE A 126
THR A 132
ARG A 149
GLY A  85
 None
 1.42A 1ia0B-4nv4A:
undetectable		 1ia0B-4nv4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		4 / 6 TYR A 109
VAL A 100
ILE A  91
LEU A 122
 None
 1.13A 1j96A-4nv4A:
undetectable		 1j96A-4nv4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 HIS A  90
PHE A 126
THR A 132
ARG A 149
GLY A  85
 None
 1.42A 1tubB-4nv4A:
undetectable		 1tubB-4nv4A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		4 / 8 LEU A 131
ARG A 149
PRO A 138
GLY A  85
 None
 1.03A 2qd5B-4nv4A:
undetectable		 2qd5B-4nv4A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		4 / 6 PHE A 143
PHE A 126
HIS A 157
VAL A 145
 None
None
PG4  A 201 (-3.9A)
None
 1.14A 3lb3B-4nv4A:
undetectable		 3lb3B-4nv4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 LEU A 110
HIS A 157
PHE A 126
THR A 132
GLY A 159
 None
PG4  A 201 (-3.9A)
None
None
None
 1.31A 4hvcB-4nv4A:
undetectable		 4hvcB-4nv4A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 THR A 132
THR A 123
ASP A 154
HIS A 157
PHE A 143
 None
None
None
PG4  A 201 (-3.9A)
None
 1.45A 5m5kB-4nv4A:
undetectable		 5m5kB-4nv4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 LEU A 110
HIS A 157
PHE A 126
THR A 132
GLY A 159
 None
PG4  A 201 (-3.9A)
None
None
None
 1.27A 5xipA-4nv4A:
undetectable		 5xipA-4nv4A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 LEU A 110
HIS A 157
PHE A 126
THR A 132
GLY A 159
 None
PG4  A 201 (-3.9A)
None
None
None
 1.25A 5xipC-4nv4A:
undetectable		 5xipC-4nv4A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 LEU A 110
HIS A 157
PHE A 126
THR A 132
GLY A 159
 None
PG4  A 201 (-3.9A)
None
None
None
 1.32A 5xiqA-4nv4A:
undetectable		 5xiqA-4nv4A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 LEU A 110
HIS A 157
PHE A 126
THR A 132
GLY A 159
 None
PG4  A 201 (-3.9A)
None
None
None
 1.29A 5xiqD-4nv4A:
undetectable		 5xiqD-4nv4A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4nv4 SIGNAL PEPTIDASE I
(Bacillus
anthracis) 		5 / 12 TYR A 109
LEU A 110
SER A 155
ILE A  84
PHE A 126
 None
 1.04A 6djzB-4nv4A:
undetectable		 6djzB-4nv4A:
20.09