SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 PHE A 163
ASP A 180
ARG A 110
ARG A  97
ILE A 107
 None
 1.49A 1i6vC-4nv7A:
0.0		 1i6vC-4nv7A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 11 LEU A 181
GLY A  92
GLY A  93
ILE A 125
TYR A 124
 None
 1.11A 1p91A-4nv7A:
undetectable		 1p91A-4nv7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 6 TYR A 189
HIS A  82
PRO A 183
VAL A  91
 None
 1.43A 1q13A-4nv7A:
undetectable		 1q13A-4nv7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 4 LEU A  78
SER A 190
LEU A  57
LEU A  60
 None
 1.18A 1yajA-4nv7A:
undetectable		 1yajA-4nv7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 11 GLY A  50
ILE A 258
ALA A 247
VAL A 208
ILE A 273
 None
 1.13A 2nnhA-4nv7A:
undetectable		 2nnhA-4nv7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 9 GLY A  50
ILE A 258
VAL A 208
ILE A 273
VAL A 274
 None
 1.25A 2nnhB-4nv7A:
undetectable		 2nnhB-4nv7A:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 6 TYR A  72
CYH A  73
VAL A  98
PHE A 204
 COA  A 301 ( 4.4A)
COA  A 301 (-2.5A)
COA  A 301 ( 4.9A)
COA  A 301 ( 4.8A)
 0.34A 3ltwA-4nv7A:
39.3		 3ltwA-4nv7A:
38.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 6 GLU A 152
PRO A 153
ARG A 218
HIS A 229
 COA  A 301 (-3.7A)
None
None
COA  A 301 (-3.4A)
 0.27A 3ltwA-4nv7A:
39.3		 3ltwA-4nv7A:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 6 SER A  25
LEU A  26
ASP A  27
LEU A 119
 None
 0.44A 4wozA-4nv7A:
undetectable
4wozB-4nv7A:
undetectable		 4wozA-4nv7A:
22.87
4wozB-4nv7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		6 / 12 GLY A 129
TYR A  72
LEU A 176
GLY A 132
GLY A  70
PHE A 204
 None
COA  A 301 ( 4.4A)
None
COA  A 301 (-3.6A)
None
COA  A 301 ( 4.8A)
 1.35A 5d4uA-4nv7A:
undetectable		 5d4uA-4nv7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 6 ILE A 273
ALA A 243
LEU A 246
ILE A 240
 None
 0.80A 5mvmB-4nv7A:
undetectable
5mvmC-4nv7A:
undetectable		 5mvmB-4nv7A:
14.74
5mvmC-4nv7A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4nv7 ARYLAMINE
N-ACETYLTRANSFERASE
(Mesorhizobium
japonicum) 		3 / 3 LEU A  87
LEU A   9
ARG A  22
 None
 0.66A 6fgdA-4nv7A:
undetectable		 6fgdA-4nv7A:
22.27