SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		4 / 5 LEU A  87
LEU A  51
LEU A  25
GLY A  66
 None
 1.01A 1a4lC-4nvtA:
4.9		 1a4lC-4nvtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 9 LEU A  32
ILE A  28
LEU A   8
VAL A 234
GLY A  11
 None
 1.20A 1e7aB-4nvtA:
undetectable		 1e7aB-4nvtA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 11 GLY A  11
ALA A  10
ILE A 165
GLY A 212
ILE A 128
 None
 1.03A 2b60B-4nvtA:
undetectable		 2b60B-4nvtA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 9 GLY A  19
THR A  93
VAL A  46
ILE A  44
VAL A  43
 None
 1.26A 2nnhB-4nvtA:
undetectable		 2nnhB-4nvtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 12 ALA A 167
ALA A 232
GLY A 235
ILE A 128
HIS A  99
 None
 0.91A 2x1lB-4nvtA:
undetectable		 2x1lB-4nvtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 11 ALA A 167
ALA A 232
GLY A 235
ILE A 128
HIS A  99
 None
 0.93A 2x1lC-4nvtA:
undetectable		 2x1lC-4nvtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 12 ARG A 208
ALA A  10
ILE A 165
SER A 238
ALA A 220
 None
 1.25A 3axtA-4nvtA:
undetectable		 3axtA-4nvtA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 12 GLY A 235
LEU A 210
GLY A 212
PHE A 244
LEU A 239
 None
 1.07A 3vywC-4nvtA:
undetectable		 3vywC-4nvtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		4 / 5 PHE A 244
LEU A   8
GLY A 231
VAL A 215
 None
 0.84A 3wrkA-4nvtA:
undetectable		 3wrkA-4nvtA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		4 / 5 PHE A 244
LEU A   8
GLY A 231
VAL A 215
 None
 0.84A 3wrkD-4nvtA:
undetectable		 3wrkD-4nvtA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		4 / 7 GLU A 137
GLU A 133
LEU A 151
ARG A 103
 None
 1.21A 4twdF-4nvtA:
undetectable
4twdJ-4nvtA:
undetectable		 4twdF-4nvtA:
20.68
4twdJ-4nvtA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 9 ARG A 103
VAL A 131
LEU A 112
LEU A 155
THR A 117
 None
 1.30A 4ubsA-4nvtA:
undetectable		 4ubsA-4nvtA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 9 LEU A  65
GLY A  66
ILE A  28
SER A 238
VAL A  46
 None
 1.27A 4x3mA-4nvtA:
3.6		 4x3mA-4nvtA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		5 / 9 LEU A  65
GLY A  66
ILE A  28
SER A 238
VAL A  46
 None
 1.22A 4x3mB-4nvtA:
3.4		 4x3mB-4nvtA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4nvt TRIOSEPHOSPHATE
ISOMERASE
(Brucella
melitensis) 		4 / 7 LYS A  88
LEU A  87
GLY A  66
GLY A  67
 None
 0.66A 5a06B-4nvtA:
undetectable		 5a06B-4nvtA:
21.79