SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		4 / 5 PHE A 231
PHE A 240
HIS A 266
VAL A 257
 None
SO4  A 403 (-3.6A)
None
GOL  A 407 (-4.1A)
 1.11A 2lh6A-4nw4A:
undetectable		 2lh6A-4nw4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		5 / 11 ALA A  88
LEU A  87
ARG A 108
ILE A  85
GLY A  66
 SO4  A 402 ( 4.8A)
None
None
None
None
 1.40A 3bpxA-4nw4A:
undetectable
3bpxB-4nw4A:
undetectable		 3bpxA-4nw4A:
18.03
3bpxB-4nw4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		5 / 11 ALA A 229
LEU A 228
ARG A 249
ILE A 226
GLY A 207
 SO4  A 403 ( 4.2A)
None
SO4  A 405 (-3.7A)
None
None
 1.42A 3bpxA-4nw4A:
undetectable
3bpxB-4nw4A:
undetectable		 3bpxA-4nw4A:
18.03
3bpxB-4nw4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		3 / 3 ASN A 297
ASP A 217
ARG A 249
 None
None
SO4  A 405 (-3.7A)
 0.75A 3k13A-4nw4A:
undetectable		 3k13A-4nw4A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		3 / 3 ASN A 297
ASP A 217
ARG A 249
 None
None
SO4  A 405 (-3.7A)
 0.84A 3k13C-4nw4A:
undetectable		 3k13C-4nw4A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		3 / 3 THR A 208
ASN A 206
GLU A 309
 None
 0.72A 3v4tA-4nw4A:
undetectable
3v4tC-4nw4A:
undetectable		 3v4tA-4nw4A:
21.09
3v4tC-4nw4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		4 / 4 LEU A 138
ILE A 126
TYR A 254
TYR A  90
 GOL  A 409 (-4.8A)
None
None
None
 1.30A 3vt7A-4nw4A:
undetectable		 3vt7A-4nw4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		3 / 3 TYR A 148
PHE A  99
ARG A 123
 SO4  A 402 (-4.4A)
SO4  A 402 (-4.0A)
SO4  A 402 (-2.9A)
 1.19A 4g19D-4nw4A:
undetectable		 4g19D-4nw4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		4 / 9 TYR A  90
HIS A 166
PHE A  99
ILE A 124
 None
SO4  A 402 (-3.9A)
SO4  A 402 (-4.0A)
None
 1.30A 4jvlA-4nw4A:
undetectable		 4jvlA-4nw4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4nw4 LIPOPROTEIN S-LAYER
PROTEIN
(Enterococcus
faecalis) 		4 / 5 TYR A 238
VAL A 304
PHE A 241
GLY A 250
 None
 1.41A 6hd4A-4nw4A:
undetectable		 6hd4A-4nw4A:
14.29