SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HMY_A_SAMA328_0 (HAEIII METHYLTRANSFERASE)	4nwb	MRNA TURNOVER PROTEIN 4 (Chaetomium thermophilum)	4 / 8	PHE A 116 ASP A 111 ILE A 112 LEU A 60	None	0.91A	1hmyA-4nwbA: undetectable	1hmyA-4nwbA: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMA_A_CXXA603_1 (TRANSPORTER)	4nwb	MRNA TURNOVER PROTEIN 4 (Chaetomium thermophilum)	5 / 11	ALA A 86 SER A 228 SER A 229 GLY A 232 THR A 93	None	1.28A	4mmaA-4nwbA: undetectable	4mmaA-4nwbA: 15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HPU_A_IPHA101_0 (INSULIN, CHAIN A INSULIN, CHAIN B)	4nwb	MRNA TURNOVER PROTEIN 4 (Chaetomium thermophilum)	4 / 4	CYH A 195 LEU A 216 LEU A 201 ALA A 125	None	1.13A	5hpuA-4nwbA: undetectable 5hpuB-4nwbA: undetectable	5hpuA-4nwbA: 14.66 5hpuB-4nwbA: 7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCE_A_RITA602_2 (CYTOCHROME P450 3A4)	4nwb	MRNA TURNOVER PROTEIN 4 (Chaetomium thermophilum)	4 / 6	ARG A 25 PHE A 66 ILE A 34 THR A 33	None	1.07A	5vceA-4nwbA: undetectable	5vceA-4nwbA: 21.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HMY_A_SAMA328_0","HAEIII METHYLTRANSFERASE","4nwb","MRNA TURNOVER PROTEIN 4","Chaetomium thermophilum",4,"PHE A 116;ASP A 111;ILE A 112;LEU A  60","None","0.91A","1hmyA-4nwbA:undetectable","1hmyA-4nwbA:21.14"],["4MMA_A_CXXA603_1","TRANSPORTER","4nwb","MRNA TURNOVER PROTEIN 4","Chaetomium thermophilum",5,"ALA A  86;SER A 228;SER A 229;GLY A 232;THR A  93","None","1.28A","4mmaA-4nwbA:undetectable","4mmaA-4nwbA:15.85"],["5HPU_A_IPHA101_0","INSULIN, CHAIN A;INSULIN, CHAIN B","4nwb","MRNA TURNOVER PROTEIN 4","Chaetomium thermophilum",4,"CYH A 195;LEU A 216;LEU A 201;ALA A 125","None","1.13A","5hpuA-4nwbA:undetectable;5hpuB-4nwbA:undetectable","5hpuA-4nwbA:14.66;5hpuB-4nwbA:7.85"],["5VCE_A_RITA602_2","CYTOCHROME P450 3A4","4nwb","MRNA TURNOVER PROTEIN 4","Chaetomium thermophilum",4,"ARG A  25;PHE A  66;ILE A  34;THR A  33","None","1.07A","5vceA-4nwbA:undetectable","5vceA-4nwbA:21.00"]]