SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
5 / 12 ILE A 150
ALA A  31
LEU A  32
LEU A 132
ILE A 139
None
1.18A 1bsxB-4nwoA:
undetectable
1bsxB-4nwoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
5 / 12 ARG A 173
LEU A 143
LEU A  36
LEU A 162
PRO A 151
None
1.49A 1p33A-4nwoA:
2.1
1p33A-4nwoA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
5 / 12 ARG A 173
LEU A 143
LEU A  36
LEU A 162
PRO A 151
None
1.36A 1p33B-4nwoA:
undetectable
1p33B-4nwoA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
5 / 12 ALA A  62
LEU A 123
ILE A 154
PHE A  99
MET A  96
None
1.36A 3qt0A-4nwoA:
undetectable
3qt0A-4nwoA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
3 / 3 ARG A 173
GLU A 158
TYR A 152
None
0.94A 4r29D-4nwoA:
undetectable
4r29D-4nwoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
4 / 6 ALA A  87
THR A  88
VAL A  91
VAL A   9
None
0.77A 5eckA-4nwoA:
undetectable
5eckA-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
4 / 6 ALA A  87
THR A  88
VAL A  91
VAL A   9
None
0.82A 5eckD-4nwoA:
undetectable
5eckD-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
4 / 6 ALA A  87
THR A  88
VAL A  91
VAL A   9
None
0.53A 5eclA-4nwoA:
undetectable
5eclA-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
4 / 6 ALA A  87
THR A  88
VAL A  91
VAL A   9
None
0.58A 5eclD-4nwoA:
undetectable
5eclD-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
4 / 7 ALA A  87
THR A  88
VAL A  91
VAL A   9
None
0.77A 5ecoD-4nwoA:
undetectable
5ecoD-4nwoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
4 / 4 SER A 107
THR A  76
ASP A  49
ASP A 135
None
1.41A 5vimA-4nwoA:
undetectable
5vimA-4nwoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)
4nwo MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
MOGA

(Shewanella
oneidensis)
4 / 4 SER A 107
THR A  76
ASP A  49
ASP A 135
None
1.47A 5vimB-4nwoA:
undetectable
5vimB-4nwoA:
21.34