SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4nww CAPSID PROTEIN
(Orsay
virus) 		4 / 5 SER A 133
GLY A  68
HIS A 154
ASP A 188
 None
 1.00A 2oxtB-4nwwA:
undetectable		 2oxtB-4nwwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4nww CAPSID PROTEIN
(Orsay
virus) 		5 / 10 ILE A  80
GLY A 374
PHE A 377
PRO A 364
ARG A 383
 None
 1.06A 3elzB-4nwwA:
undetectable		 3elzB-4nwwA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4nww CAPSID PROTEIN
(Orsay
virus) 		4 / 8 PHE A 266
PHE A 268
ILE A 300
PHE A 377
 None
 0.90A 3ko0O-4nwwA:
undetectable
3ko0Q-4nwwA:
undetectable		 3ko0O-4nwwA:
14.53
3ko0Q-4nwwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4nww CAPSID PROTEIN
(Orsay
virus) 		4 / 5 LEU A 207
LEU A  84
GLY A  85
THR A 165
 None
 0.78A 3si7C-4nwwA:
undetectable
3si7D-4nwwA:
undetectable		 3si7C-4nwwA:
18.90
3si7D-4nwwA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4nww CAPSID PROTEIN
(Orsay
virus) 		4 / 5 SER A 366
PRO A 364
TYR A 381
VAL A 363
 None
 1.40A 3sufC-4nwwA:
undetectable		 3sufC-4nwwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4nww CAPSID PROTEIN
(Orsay
virus) 		4 / 7 THR A 152
LEU A 137
VAL A 199
VAL A 103
 None
 0.75A 4cp4A-4nwwA:
undetectable		 4cp4A-4nwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4nww CAPSID PROTEIN
(Orsay
virus) 		4 / 6 ASP A 312
GLY A 243
PRO A 330
THR A 331
 None
 0.94A 4l1aB-4nwwA:
undetectable		 4l1aB-4nwwA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4nww CAPSID PROTEIN
(Orsay
virus) 		5 / 10 ILE A  76
GLY A 118
PHE A 101
SER A  73
VAL A 156
 None
 1.09A 5i6xA-4nwwA:
undetectable		 5i6xA-4nwwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4nww CAPSID PROTEIN
(Orsay
virus) 		3 / 3 LYS A  51
LEU A  49
ARG A  97
 None
 0.95A 5yw0A-4nwwA:
undetectable		 5yw0A-4nwwA:
19.13