SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZTH_A_SAMA305_1 (CATECHOL O-METHYLTRANSFERASE)	4nwy	PROTEIN DISULFIDE-ISOMERASE- LIKE PROTEIN OF THE TESTIS (Homo sapiens)	3 / 3	SER A 351 GLU A 357 ASP A 353	None	0.76A	2zthA-4nwyA: undetectable	2zthA-4nwyA: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9H_A_NCAA1163_0 (TANKYRASE-2)	4nwy	PROTEIN DISULFIDE-ISOMERASE- LIKE PROTEIN OF THE TESTIS (Homo sapiens)	4 / 8	HIS A 295 ALA A 299 LYS A 360 GLU A 302	None	0.81A	3u9hA-4nwyA: undetectable	3u9hA-4nwyA: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9H_B_NCAB1164_0 (TANKYRASE-2)	4nwy	PROTEIN DISULFIDE-ISOMERASE- LIKE PROTEIN OF THE TESTIS (Homo sapiens)	4 / 8	HIS A 295 ALA A 299 LYS A 360 GLU A 302	None	0.78A	3u9hB-4nwyA: undetectable	3u9hB-4nwyA: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BJC_A_RPBA2162_1 (TANKYRASE-2)	4nwy	PROTEIN DISULFIDE-ISOMERASE- LIKE PROTEIN OF THE TESTIS (Homo sapiens)	4 / 8	HIS A 295 ALA A 299 LYS A 360 GLU A 302	None	0.78A	4bjcA-4nwyA: undetectable	4bjcA-4nwyA: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q0B_A_NVPA901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	4nwy	PROTEIN DISULFIDE-ISOMERASE- LIKE PROTEIN OF THE TESTIS (Homo sapiens)	4 / 8	LEU A 279 VAL A 328 TYR A 325 LEU A 339	None	1.12A	4q0bA-4nwyA: 2.2	4q0bA-4nwyA: 13.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZTH_A_SAMA305_1","CATECHOL O-METHYLTRANSFERASE","4nwy","PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS","Homo sapiens",3,"SER A 351;GLU A 357;ASP A 353","None","0.76A","2zthA-4nwyA:undetectable","2zthA-4nwyA:20.81"],["3U9H_A_NCAA1163_0","TANKYRASE-2","4nwy","PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS","Homo sapiens",4,"HIS A 295;ALA A 299;LYS A 360;GLU A 302","None","0.81A","3u9hA-4nwyA:undetectable","3u9hA-4nwyA:22.88"],["3U9H_B_NCAB1164_0","TANKYRASE-2","4nwy","PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS","Homo sapiens",4,"HIS A 295;ALA A 299;LYS A 360;GLU A 302","None","0.78A","3u9hB-4nwyA:undetectable","3u9hB-4nwyA:22.88"],["4BJC_A_RPBA2162_1","TANKYRASE-2","4nwy","PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS","Homo sapiens",4,"HIS A 295;ALA A 299;LYS A 360;GLU A 302","None","0.78A","4bjcA-4nwyA:undetectable","4bjcA-4nwyA:22.88"],["4Q0B_A_NVPA901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","4nwy","PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS","Homo sapiens",4,"LEU A 279;VAL A 328;TYR A 325;LEU A 339","None","1.12A","4q0bA-4nwyA:2.2","4q0bA-4nwyA:13.48"]]