SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nx1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 11 HIS A 235
PRO A 191
VAL A 174
GLN A 180
ILE A 179
 None
 1.46A 2vkeA-4nx1A:
0.0		 2vkeA-4nx1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 PHE A  43
PHE A 211
GLU A 212
ALA A 216
TYR A 196
 X1X  A 401 (-4.7A)
None
None
None
X1X  A 401 (-3.7A)
 1.46A 3apvB-4nx1A:
undetectable		 3apvB-4nx1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 PHE A  43
PHE A 211
GLU A 212
ALA A 216
TYR A 196
 X1X  A 401 (-4.7A)
None
None
None
X1X  A 401 (-3.7A)
 1.44A 3apwA-4nx1A:
undetectable		 3apwA-4nx1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 4 LEU A 132
ARG A 328
LEU A 113
ALA A 315
 None
 0.96A 3b9mA-4nx1A:
undetectable		 3b9mA-4nx1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 TYR A 196
MET A  36
ASN A 220
LEU A 221
 X1X  A 401 (-3.7A)
None
None
None
 1.49A 3lslG-4nx1A:
5.4		 3lslG-4nx1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 4 VAL A 327
PHE A 114
PHE A 112
VAL A 307
 None
 1.08A 3rv5C-4nx1A:
undetectable
3rv5D-4nx1A:
undetectable		 3rv5C-4nx1A:
13.84
3rv5D-4nx1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 10 SER A 245
LEU A 256
VAL A  62
PHE A  64
VAL A 260
 None
 1.26A 3u9fK-4nx1A:
undetectable		 3u9fK-4nx1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		3 / 3 GLU A  75
TYR A  78
SER A  35
 X1X  A 401 (-2.8A)
None
None
 0.90A 4at0A-4nx1A:
undetectable		 4at0A-4nx1A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 HIS A 235
PRO A 191
VAL A 174
GLN A 180
ILE A 179
 None
 1.46A 4b3aA-4nx1A:
undetectable		 4b3aA-4nx1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 5 LEU A 187
LEU A 167
MET A 172
THR A 233
 None
 1.41A 4do3A-4nx1A:
undetectable		 4do3A-4nx1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 11 ASP A 279
ASN A 213
GLU A 212
SER A 236
HIS A 235
 None
X1X  A 401 (-3.1A)
None
None
None
 1.30A 4fewE-4nx1A:
0.0
4fewF-4nx1A:
0.0		 4fewE-4nx1A:
20.06
4fewF-4nx1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		3 / 3 LEU A 113
MET A 110
ASP A 127
 None
 0.77A 4j7xB-4nx1A:
undetectable		 4j7xB-4nx1A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 9 TYR A  78
VAL A 243
ILE A 242
LEU A  68
LEU A  66
 None
 1.44A 4l1xB-4nx1A:
undetectable		 4l1xB-4nx1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 4 THR A  44
GLY A  33
ASP A  65
SER A  35
 None
 1.09A 4rfqA-4nx1A:
undetectable		 4rfqA-4nx1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 HIS A 235
PRO A 191
VAL A 174
GLN A 180
ILE A 179
 None
 1.45A 4v2gB-4nx1A:
undetectable		 4v2gB-4nx1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 GLY A 271
SER A 276
GLY A 150
ALA A 269
 None
 0.95A 5e26A-4nx1A:
undetectable
5e26B-4nx1A:
undetectable		 5e26A-4nx1A:
22.39
5e26B-4nx1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 ALA A 269
GLY A 271
SER A 276
GLY A 150
 None
 0.89A 5e26A-4nx1A:
undetectable
5e26B-4nx1A:
undetectable		 5e26A-4nx1A:
22.39
5e26B-4nx1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 GLY A 271
SER A 276
GLY A 150
ALA A 269
 None
 0.89A 5e26C-4nx1A:
undetectable
5e26D-4nx1A:
undetectable		 5e26C-4nx1A:
22.39
5e26D-4nx1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 8 ALA A 269
GLY A 271
SER A 276
GLY A 150
 None
 0.86A 5e26C-4nx1A:
undetectable
5e26D-4nx1A:
undetectable		 5e26C-4nx1A:
22.39
5e26D-4nx1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A 150
TYR A 196
ILE A 194
GLY A 210
THR A 152
 None
X1X  A 401 (-3.7A)
None
None
None
 1.18A 5eskA-4nx1A:
undetectable		 5eskA-4nx1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A 150
TYR A 196
ILE A 194
GLY A 210
THR A 152
 None
X1X  A 401 (-3.7A)
None
None
None
 1.25A 5eslA-4nx1A:
undetectable		 5eslA-4nx1A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 ARG A 153
GLY A 149
GLU A 214
SER A 217
 X1X  A 401 (-3.1A)
None
X1X  A 401 (-2.7A)
X1X  A 401 (-3.7A)
 1.06A 5ny7A-4nx1A:
undetectable		 5ny7A-4nx1A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 PHE A 297
MET A 303
MET A 172
THR A 188
 None
 1.30A 5u6mA-4nx1A:
undetectable		 5u6mA-4nx1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 THR A 233
HIS A 235
MET A 172
MET A 303
 None
 1.23A 5u6mA-4nx1A:
undetectable		 5u6mA-4nx1A:
22.99