SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 5 THR A 174
GLU A 103
THR A 114
HIS A 205
 None
 1.40A 1d4fA-4nx8A:
undetectable		 1d4fA-4nx8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 5 THR A 174
GLU A 103
THR A 114
HIS A 205
 None
 1.46A 1d4fD-4nx8A:
undetectable		 1d4fD-4nx8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 8 ARG A 212
VAL A 175
ASN A 123
ASP A 120
 None
 1.24A 1hwiB-4nx8A:
undetectable		 1hwiB-4nx8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 7 ARG A 212
VAL A 175
ASN A 123
ASP A 120
 None
 1.35A 1hwiC-4nx8A:
undetectable		 1hwiC-4nx8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 7 ARG A 212
VAL A 175
ASN A 123
ASP A 120
 None
 1.35A 1hwiD-4nx8A:
undetectable		 1hwiD-4nx8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 5 GLU A 130
ARG A 172
ASP A  99
THR A 114
 MG  A 303 ( 3.8A)
None
None
None
 1.45A 1k4tA-4nx8A:
0.6		 1k4tA-4nx8A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_A_KANA1300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		5 / 10 ASP A  99
ASP A  51
ARG A 101
ASP A 120
GLU A 159
 None
 1.48A 1nd4A-4nx8A:
0.0		 1nd4A-4nx8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 5 GLU A 130
ARG A 172
ASP A  99
THR A 114
 MG  A 303 ( 3.8A)
None
None
None
 1.50A 1rrjA-4nx8A:
0.5		 1rrjA-4nx8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		3 / 3 THR A 213
GLU A 103
HIS A 178
 None
 0.82A 1xwfA-4nx8A:
undetectable		 1xwfA-4nx8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		3 / 3 THR A 213
GLU A 103
HIS A 178
 None
 0.87A 1xwfB-4nx8A:
undetectable		 1xwfB-4nx8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		3 / 3 THR A 213
GLU A 103
HIS A 178
 None
 0.85A 1xwfC-4nx8A:
undetectable		 1xwfC-4nx8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		3 / 3 THR A 213
GLU A 103
HIS A 178
 None
 0.86A 1xwfD-4nx8A:
1.9		 1xwfD-4nx8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 6 TYR A 170
GLY A  72
PHE A 204
SER A  71
 None
 1.37A 2a3cA-4nx8A:
undetectable		 2a3cA-4nx8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 6 TYR A 170
GLY A  72
PHE A 204
SER A  71
 None
 1.31A 2a3cB-4nx8A:
undetectable		 2a3cB-4nx8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		5 / 12 ASP A 244
ARG A 207
THR A 214
ALA A 122
THR A  43
 None
 1.30A 3ua1A-4nx8A:
undetectable		 3ua1A-4nx8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		5 / 12 ILE A 156
THR A 151
ILE A 148
LEU A  48
ILE A 108
 None
GOL  A 302 (-3.9A)
None
None
None
 1.01A 4kjkA-4nx8A:
undetectable		 4kjkA-4nx8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		4 / 8 ARG A 137
ASP A 146
LEU A 142
ILE A 108
 None
 1.07A 4l7iA-4nx8A:
undetectable		 4l7iA-4nx8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		5 / 12 ILE A 156
THR A 151
ILE A 148
LEU A  48
ILE A 108
 None
GOL  A 302 (-3.9A)
None
None
None
 1.06A 4p3qA-4nx8A:
undetectable		 4p3qA-4nx8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		5 / 12 ILE A 156
THR A 151
ILE A 148
LEU A  48
ILE A 108
 None
GOL  A 302 (-3.9A)
None
None
None
 1.05A 4pthA-4nx8A:
undetectable		 4pthA-4nx8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2
(Bdellovibrio
bacteriovorus) 		3 / 3 ARG A 212
GLN A 102
GLU A 103
 None
 0.88A 4tvtA-4nx8A:
undetectable		 4tvtA-4nx8A:
19.57