SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nx9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 141
LEU A  81
GLY A 318
GLY A  70
LEU A  73
 None
 1.11A 1igxA-4nx9A:
undetectable		 1igxA-4nx9A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 12 THR A 253
GLY A 251
GLU A 280
SER A 248
ASP A 250
 None
 1.40A 1jdvE-4nx9A:
undetectable
1jdvF-4nx9A:
undetectable		 1jdvE-4nx9A:
23.86
1jdvF-4nx9A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 295
ILE A 290
VAL A 302
SER A  95
 None
 1.01A 1rs7B-4nx9A:
undetectable		 1rs7B-4nx9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  71
ILE A 156
VAL A 158
ALA A 144
LEU A 136
 None
 0.96A 1uduB-4nx9A:
undetectable		 1uduB-4nx9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 11 SER A 150
ARG A 323
VAL A 148
GLN A 147
ILE A 155
 None
 1.37A 2trtA-4nx9A:
undetectable		 2trtA-4nx9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 11 SER A 150
ARG A 323
VAL A 148
GLN A 147
ILE A 155
 None
 1.32A 2vkeA-4nx9A:
0.8		 2vkeA-4nx9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 10 THR A 275
TYR A 243
VAL A 181
GLY A 178
GLY A 179
 None
 1.46A 3ixlA-4nx9A:
undetectable		 3ixlA-4nx9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 12 SER A 150
ARG A 323
VAL A 148
GLN A 147
ILE A 155
 None
 1.39A 4b3aA-4nx9A:
2.3		 4b3aA-4nx9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		4 / 4 PHE A 235
VAL A 244
ALA A 234
PHE A 278
 None
 1.49A 4f3tA-4nx9A:
2.9		 4f3tA-4nx9A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 311
ARG A 314
ASP A 304
 None
 0.83A 4fp9C-4nx9A:
undetectable		 4fp9C-4nx9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 311
ARG A 314
ASP A 304
 None
 0.81A 4fp9F-4nx9A:
undetectable		 4fp9F-4nx9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 261
ALA A 222
ALA A 234
ILE A 194
VAL A 259
 None
 1.07A 4h1nA-4nx9A:
undetectable		 4h1nA-4nx9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 269
THR A 182
ALA A 214
VAL A 190
GLY A 210
 None
 1.03A 4qvyK-4nx9A:
undetectable
4qvyL-4nx9A:
undetectable		 4qvyK-4nx9A:
20.07
4qvyL-4nx9A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 269
THR A 182
ALA A 214
VAL A 190
GLY A 210
 None
 1.03A 4qvyY-4nx9A:
undetectable
4qvyZ-4nx9A:
undetectable		 4qvyY-4nx9A:
20.07
4qvyZ-4nx9A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4nx9 FLAGELLIN
(Pseudomonas
aeruginosa) 		3 / 3 SER A 248
ALA A 247
THR A 171
 None
 0.74A 5n0xB-4nx9A:
undetectable		 5n0xB-4nx9A:
22.33