SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4nxi UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 181
VAL A  35
TRP A  28
 None
 1.22A 1c4dA-4nxiA:
undetectable
1c4dB-4nxiA:
undetectable		 1c4dA-4nxiA:
6.47
1c4dB-4nxiA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4nxi UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  18
LEU A 106
VAL A  74
ALA A  77
LEU A 136
 None
 0.92A 1tbfA-4nxiA:
undetectable		 1tbfA-4nxiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4nxi UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 114
LEU A  87
ALA A  81
GLU A  79
ALA A  75
 None
None
None
MG  A 301 ( 4.0A)
None
 1.02A 3mdvA-4nxiA:
undetectable		 3mdvA-4nxiA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4nxi UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  13
VAL A  32
TRP A  28
PRO A 154
 None
 1.33A 3n6dA-4nxiA:
undetectable
3n6dB-4nxiA:
undetectable		 3n6dA-4nxiA:
18.06
3n6dB-4nxiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4nxi UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  68
SER A  46
LEU A 136
ILE A  76
PHE A  15
 None
 1.26A 5vlmA-4nxiA:
undetectable		 5vlmA-4nxiA:
22.94