SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 324
ILE A 322
ALA A 285
MET A 266
 None
 1.17A 1hk2A-4nxkA:
undetectable		 1hk2A-4nxkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 161
HIS A 126
MET A 128
 GOL  A 511 ( 4.0A)
GOL  A 510 (-3.9A)
None
 1.22A 1l5qB-4nxkA:
1.9		 1l5qB-4nxkA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 342
LEU A 345
MET A  27
LEU A 334
TYR A  50
 None
 1.12A 1sqnA-4nxkA:
undetectable		 1sqnA-4nxkA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 THR A 319
VAL A 371
VAL A 383
LEU A 430
ILE A 436
 None
 1.42A 1t6zB-4nxkA:
undetectable		 1t6zB-4nxkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 ALA A  52
TYR A  54
ALA A  48
TYR A  50
 None
 1.07A 1xl6A-4nxkA:
undetectable
1xl6B-4nxkA:
undetectable		 1xl6A-4nxkA:
23.27
1xl6B-4nxkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 319
TRP A 340
TRP A 260
GLU A 390
 None
 1.49A 1xr2B-4nxkA:
undetectable		 1xr2B-4nxkA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 MET A 329
LEU A 290
GLY A 291
LEU A 345
 None
 0.95A 1ya4A-4nxkA:
undetectable		 1ya4A-4nxkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A 288
PRO A 289
LEU A 290
ARG A 315
 None
 1.33A 2hrcA-4nxkA:
undetectable		 2hrcA-4nxkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PRO A 283
MET A 249
ASP A 255
ASP A 286
 None
None
GOL  A 511 ( 2.9A)
GOL  A 510 ( 4.6A)
 1.32A 2lh8A-4nxkA:
undetectable		 2lh8A-4nxkA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 342
LEU A 345
MET A  27
LEU A 334
TYR A  50
 None
 1.09A 2w8yB-4nxkA:
undetectable		 2w8yB-4nxkA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 ALA A  52
TYR A  54
ALA A  48
TYR A  50
 None
 1.08A 2wlkA-4nxkA:
undetectable
2wlkB-4nxkA:
undetectable		 2wlkA-4nxkA:
23.27
2wlkB-4nxkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A 288
PRO A 289
LEU A 290
ARG A 315
 None
 1.35A 3hcoB-4nxkA:
undetectable		 3hcoB-4nxkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 277
TYR A 358
GLY A 278
PHE A 324
PRO A 327
 None
None
SO4  A 507 (-3.5A)
None
None
 1.23A 3mecA-4nxkA:
undetectable		 3mecA-4nxkA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 TRP A  21
ILE A 219
GLY A 280
VAL A 227
ASN A 248
 SO4  A 501 (-4.2A)
None
None
None
None
 1.43A 3rlbB-4nxkA:
undetectable		 3rlbB-4nxkA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 173
ASP A 169
ILE A 152
ILE A 131
 SO4  A 502 (-2.5A)
CIT  A 513 ( 4.9A)
None
None
 0.89A 4kttD-4nxkA:
undetectable		 4kttD-4nxkA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 334
ARG A 335
VAL A  63
LEU A 121
LEU A  55
 None
 1.24A 4or0B-4nxkA:
undetectable		 4or0B-4nxkA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 357
SER A 374
PHE A 382
HIS A 352
 None
 1.07A 4ws0A-4nxkA:
undetectable		 4ws0A-4nxkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 136
TYR A 166
ALA A 153
 None
 0.50A 4ybnA-4nxkA:
undetectable		 4ybnA-4nxkA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 216
ASN A 248
ASP A 192
 None
 0.90A 5gwxA-4nxkA:
undetectable		 5gwxA-4nxkA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 173
ASP A 169
ILE A 152
ILE A 131
 SO4  A 502 (-2.5A)
CIT  A 513 ( 4.9A)
None
None
 0.94A 5t8sA-4nxkA:
undetectable		 5t8sA-4nxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 ARG A  99
SER A  31
ASP A  66
HIS A 126
 None
None
GOL  A 510 (-2.7A)
GOL  A 510 (-3.9A)
 1.27A 5zhmA-4nxkA:
undetectable		 5zhmA-4nxkA:
20.97