SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4nxy ACYL-COA SYNTHETASE
(Streptomyces
lividans) 		4 / 8 ALA A  46
THR A  42
ILE A  41
THR A  81
 None
 0.83A 3bpxA-4nxyA:
undetectable
3bpxB-4nxyA:
undetectable		 3bpxA-4nxyA:
19.31
3bpxB-4nxyA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4nxy ACYL-COA SYNTHETASE
(Streptomyces
lividans) 		5 / 12 VAL A  43
ASP A  45
GLY A  96
ALA A  92
ALA A  93
 None
 1.10A 3sueC-4nxyA:
undetectable		 3sueC-4nxyA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4nxy ACYL-COA SYNTHETASE
(Streptomyces
lividans) 		5 / 10 ALA A 122
VAL A 103
ALA A 146
ALA A 149
ILE A 145
 None
 1.07A 4lbgA-4nxyA:
undetectable		 4lbgA-4nxyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4nxy ACYL-COA SYNTHETASE
(Streptomyces
lividans) 		5 / 9 ALA A 122
VAL A 103
ALA A 146
ALA A 149
ILE A 145
 None
 1.10A 4lbgB-4nxyA:
undetectable		 4lbgB-4nxyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4nxy ACYL-COA SYNTHETASE
(Streptomyces
lividans) 		3 / 3 ASP A 106
PHE A  80
ARG A  64
 None
ETF  A 201 (-3.8A)
None
 1.06A 5yw0A-4nxyA:
undetectable		 5yw0A-4nxyA:
20.43