SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		3 / 3 ALA A 188
VAL A  87
TRP A  89
 None
 0.65A 1bdwA-4nynA:
undetectable
1bdwB-4nynA:
undetectable		 1bdwA-4nynA:
8.00
1bdwB-4nynA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		5 / 9 GLY A 171
ASP A 173
ASP A 174
GLY A  67
ILE A 134
 None
 1.12A 1hxwA-4nynA:
undetectable		 1hxwA-4nynA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		3 / 3 GLU A 167
LYS A 161
VAL A 163
 None
 0.92A 1l2iA-4nynA:
undetectable		 1l2iA-4nynA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		5 / 10 ARG A 137
ALA A 126
GLY A  67
GLY A  68
ILE A 134
 None
 0.91A 1sdvA-4nynA:
undetectable		 1sdvA-4nynA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		3 / 3 ASP A 117
PHE A  74
ASN A 111
 None
 0.66A 1sg9B-4nynA:
undetectable		 1sg9B-4nynA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		5 / 12 ALA A  86
GLY A  76
ASN A 112
ASP A 189
GLY A 103
 None
None
None
MN  A 302 (-3.1A)
None
 1.14A 2f8lA-4nynA:
undetectable		 2f8lA-4nynA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		4 / 7 LEU A 123
ALA A 126
PHE A 131
PHE A 172
 None
 0.81A 2vcvL-4nynA:
undetectable		 2vcvL-4nynA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		4 / 4 ALA A 118
ALA A 121
ALA A 122
ALA A 125
 None
 0.12A 4oadA-4nynA:
undetectable		 4oadA-4nynA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		4 / 4 ALA A 118
ALA A 121
ALA A 122
ALA A 125
 None
 0.13A 4oaeA-4nynA:
undetectable		 4oaeA-4nynA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		5 / 12 ALA A 121
ALA A  85
ILE A 106
ASN A 185
GLY A 102
 None
 1.17A 4r38A-4nynA:
undetectable		 4r38A-4nynA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		5 / 12 ALA A 121
ALA A  85
ILE A 106
ASN A 185
GLY A 102
 None
 1.18A 4r38B-4nynA:
undetectable		 4r38B-4nynA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		5 / 12 ALA A 121
ALA A  85
ILE A 106
ASN A 185
GLY A 102
 None
 1.20A 4r38C-4nynA:
undetectable		 4r38C-4nynA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		5 / 12 ALA A 121
ALA A  85
ILE A 106
ASN A 185
GLY A 102
 None
 1.18A 4r38D-4nynA:
undetectable		 4r38D-4nynA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4nyn RIBONUCLEASE HI
(Halobacterium
salinarum) 		4 / 6 ASP A 157
ASP A 155
ARG A 160
GLN A 113
 None
 1.30A 6g31L-4nynA:
undetectable		 6g31L-4nynA:
20.11