SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 12 PHE A 262
GLY A 192
ALA A 195
SER A 196
GLY A 101
None
1.07A 1fe2A-4nz0A:
undetectable
1fe2A-4nz0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 11 PHE A 149
LEU A 301
LEU A 186
LEU A 190
HIS A 183
None
1.13A 1mx1B-4nz0A:
undetectable
1mx1B-4nz0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.10A 1p7lC-4nz0A:
undetectable
1p7lC-4nz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.10A 1p7lD-4nz0A:
undetectable
1p7lD-4nz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.11A 1rg9A-4nz0A:
undetectable
1rg9A-4nz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.11A 1rg9B-4nz0A:
undetectable
1rg9B-4nz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.09A 1rg9C-4nz0A:
undetectable
1rg9C-4nz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.10A 1rg9D-4nz0A:
undetectable
1rg9D-4nz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
0.98A 1v54A-4nz0A:
undetectable
1v54J-4nz0A:
undetectable
1v54A-4nz0A:
22.41
1v54J-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
1.00A 2dyrA-4nz0A:
undetectable
2dyrJ-4nz0A:
undetectable
2dyrA-4nz0A:
22.41
2dyrJ-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
0.99A 2dysA-4nz0A:
undetectable
2dysJ-4nz0A:
undetectable
2dysA-4nz0A:
22.41
2dysJ-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
1.01A 2dysN-4nz0A:
undetectable
2dysW-4nz0A:
undetectable
2dysN-4nz0A:
22.41
2dysW-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
0.98A 2eijA-4nz0A:
undetectable
2eijJ-4nz0A:
undetectable
2eijA-4nz0A:
22.41
2eijJ-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
0.95A 2eilA-4nz0A:
undetectable
2eilJ-4nz0A:
undetectable
2eilA-4nz0A:
22.41
2eilJ-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.20A 2obvA-4nz0A:
undetectable
2obvA-4nz0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.17A 2p02A-4nz0A:
undetectable
2p02A-4nz0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 5 TYR A 285
LEU A   3
LYS A   1
HIS A 278
None
1.45A 2wekB-4nz0A:
0.0
2wekB-4nz0A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 LEU A 113
HIS A  57
THR A 156
TYR A 154
None
1.16A 2y69C-4nz0A:
undetectable
2y69N-4nz0A:
undetectable
2y69P-4nz0A:
undetectable
2y69C-4nz0A:
19.91
2y69N-4nz0A:
22.41
2y69P-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 TYR A 236
LEU A 352
VAL A 328
VAL A 337
None
0.98A 2z97A-4nz0A:
undetectable
2z97A-4nz0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 TYR A 236
PHE A 368
ILE A 310
ASN A 306
None
0.93A 2zseA-4nz0A:
undetectable
2zseA-4nz0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 11 HIS A  57
ILE A 287
VAL A 176
HIS A 278
PRO A 179
None
1.35A 2zwgA-4nz0A:
undetectable
2zwgB-4nz0A:
undetectable
2zwgA-4nz0A:
22.06
2zwgB-4nz0A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
1.05A 2zxwA-4nz0A:
undetectable
2zxwJ-4nz0A:
undetectable
2zxwA-4nz0A:
22.41
2zxwJ-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
1.02A 3abmA-4nz0A:
undetectable
3abmJ-4nz0A:
undetectable
3abmA-4nz0A:
22.41
3abmJ-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
0.97A 3asnA-4nz0A:
undetectable
3asnJ-4nz0A:
undetectable
3asnA-4nz0A:
22.41
3asnJ-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.22A 3asoA-4nz0A:
undetectable
3asoC-4nz0A:
undetectable
3asoP-4nz0A:
undetectable
3asoA-4nz0A:
22.41
3asoC-4nz0A:
19.91
3asoP-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 329
ARG A 230
THR A 373
LEU A 374
None
0.99A 3asoA-4nz0A:
undetectable
3asoJ-4nz0A:
undetectable
3asoA-4nz0A:
22.41
3asoJ-4nz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 12 LEU A 314
VAL A 234
VAL A 328
TYR A 232
PHE A 368
None
1.12A 3mecA-4nz0A:
2.9
3mecA-4nz0A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 12 LEU A 314
VAL A 234
VAL A 328
TYR A 232
PHE A 368
None
1.14A 3medA-4nz0A:
5.8
3medB-4nz0A:
2.8
3medA-4nz0A:
22.34
3medB-4nz0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 4 ARG A 174
ASP A 235
ASP A 333
ASP A 334
None
1.06A 3naiB-4nz0A:
33.4
3naiB-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 LEU A 186
LEU A 190
LEU A 273
LEU A 270
None
1.02A 3q1eA-4nz0A:
undetectable
3q1eC-4nz0A:
undetectable
3q1eA-4nz0A:
12.89
3q1eC-4nz0A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
6 / 9 ASP A 240
ASN A 302
TYR A 331
GLY A 332
ASP A 333
ASP A 334
None
0.64A 3sfuA-4nz0A:
32.5
3sfuA-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
7 / 9 ASP A 240
ASN A 302
TYR A 331
GLY A 332
ASP A 333
ASP A 334
LEU A 380
None
0.63A 3sfuB-4nz0A:
32.4
3sfuB-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
6 / 11 ASP A 240
LEU A 291
THR A 298
ASN A 302
GLY A 332
ASP A 333
None
0.99A 3sfuC-4nz0A:
32.6
3sfuC-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
7 / 11 LYS A 159
ARG A 174
ASP A 240
LEU A 291
ASN A 302
GLY A 332
ASP A 333
None
0.90A 3sfuC-4nz0A:
32.6
3sfuC-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 10 ARG A 456
GLU A 387
LEU A 390
GLU A 452
VAL A 394
None
1.10A 3ua5B-4nz0A:
0.0
3ua5B-4nz0A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 PRO A 393
ARG A 392
GLY A 388
PRO A 389
None
1.09A 3ucbB-4nz0A:
undetectable
3ucbB-4nz0A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.17A 3wg7A-4nz0A:
undetectable
3wg7C-4nz0A:
undetectable
3wg7P-4nz0A:
undetectable
3wg7A-4nz0A:
22.41
3wg7C-4nz0A:
19.91
3wg7P-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 LEU A 113
HIS A  57
THR A 156
TYR A 154
None
1.17A 3wg7C-4nz0A:
undetectable
3wg7N-4nz0A:
undetectable
3wg7P-4nz0A:
undetectable
3wg7C-4nz0A:
19.91
3wg7N-4nz0A:
22.41
3wg7P-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 LEU A 286
TYR A 285
SER A 276
HIS A  57
None
1.37A 4arcA-4nz0A:
undetectable
4arcA-4nz0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.19A 4kttC-4nz0A:
undetectable
4kttC-4nz0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.19A 4ndnC-4nz0A:
undetectable
4ndnC-4nz0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
3 / 3 ASN A 363
ASP A 233
ASP A 333
None
0.76A 4obwD-4nz0A:
undetectable
4obwD-4nz0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.16A 4odjA-4nz0A:
undetectable
4odjA-4nz0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 10 ARG A  85
PHE A 194
LEU A 251
ILE A 304
ALA A  76
None
1.47A 4z69I-4nz0A:
undetectable
4z69I-4nz0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
3 / 3 LYS A 385
ARG A 392
HIS A 425
None
1.25A 4zbrA-4nz0A:
undetectable
4zbrA-4nz0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.14A 5a1iA-4nz0A:
undetectable
5a1iA-4nz0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.14A 5a1iA-4nz0A:
undetectable
5a1iA-4nz0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.19A 5b1aA-4nz0A:
undetectable
5b1aC-4nz0A:
undetectable
5b1aP-4nz0A:
undetectable
5b1aA-4nz0A:
22.41
5b1aC-4nz0A:
19.91
5b1aP-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.16A 5b3sA-4nz0A:
undetectable
5b3sC-4nz0A:
undetectable
5b3sP-4nz0A:
undetectable
5b3sA-4nz0A:
22.41
5b3sC-4nz0A:
19.91
5b3sP-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 THR A 130
ALA A 131
THR A 132
VAL A 126
None
0.84A 5ecoA-4nz0A:
undetectable
5ecoA-4nz0A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
6 / 12 LEU A 251
PHE A 255
TYR A  75
LEU A 206
LEU A  83
PHE A 256
None
1.41A 5ieoA-4nz0A:
undetectable
5ieoA-4nz0A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 12 LEU A 251
PHE A 255
TYR A  75
LEU A 206
LEU A  83
None
1.21A 5iepA-4nz0A:
undetectable
5iepA-4nz0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.13A 5t8sB-4nz0A:
undetectable
5t8sB-4nz0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.20A 5w97A-4nz0A:
undetectable
5w97C-4nz0A:
undetectable
5w97c-4nz0A:
undetectable
5w97A-4nz0A:
22.41
5w97C-4nz0A:
19.91
5w97c-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 LEU A 113
HIS A  57
THR A 156
TYR A 154
None
1.20A 5w97C-4nz0A:
undetectable
5w97a-4nz0A:
undetectable
5w97c-4nz0A:
undetectable
5w97C-4nz0A:
19.91
5w97a-4nz0A:
22.41
5w97c-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 10 LEU A 335
PHE A 239
LEU A 314
ALA A 312
LEU A 352
None
0.98A 5y7pB-4nz0A:
undetectable
5y7pB-4nz0A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 10 LEU A 335
PHE A 239
LEU A 314
ALA A 312
LEU A 352
None
0.94A 5y7pH-4nz0A:
undetectable
5y7pH-4nz0A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 11 HIS A  57
ILE A 287
VAL A 176
HIS A 278
PRO A 179
None
1.28A 5z0fA-4nz0A:
undetectable
5z0fB-4nz0A:
undetectable
5z0fA-4nz0A:
10.94
5z0fB-4nz0A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 11 HIS A  57
ILE A 287
VAL A 176
HIS A 278
PRO A 179
None
1.31A 5z0gA-4nz0A:
undetectable
5z0gB-4nz0A:
undetectable
5z0gA-4nz0A:
10.94
5z0gB-4nz0A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 11 HIS A  57
ILE A 287
VAL A 176
HIS A 278
PRO A 179
None
1.41A 5z0iA-4nz0A:
undetectable
5z0iB-4nz0A:
undetectable
5z0iA-4nz0A:
10.94
5z0iB-4nz0A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 11 HIS A  57
ILE A 287
VAL A 176
HIS A 278
PRO A 179
None
1.22A 5z0jA-4nz0A:
undetectable
5z0jB-4nz0A:
undetectable
5z0jA-4nz0A:
10.94
5z0jB-4nz0A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 11 HIS A  57
ILE A 287
VAL A 176
HIS A 278
PRO A 179
None
1.37A 5z0lA-4nz0A:
undetectable
5z0lB-4nz0A:
undetectable
5z0lA-4nz0A:
10.94
5z0lB-4nz0A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 11 HIS A  57
ILE A 287
VAL A 176
HIS A 278
PRO A 179
None
1.22A 5z0mA-4nz0A:
undetectable
5z0mB-4nz0A:
undetectable
5z0mA-4nz0A:
10.94
5z0mB-4nz0A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.22A 5z84A-4nz0A:
undetectable
5z84C-4nz0A:
undetectable
5z84P-4nz0A:
undetectable
5z84A-4nz0A:
22.41
5z84C-4nz0A:
19.91
5z84P-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.18A 5z85A-4nz0A:
undetectable
5z85C-4nz0A:
undetectable
5z85P-4nz0A:
undetectable
5z85A-4nz0A:
22.41
5z85C-4nz0A:
19.91
5z85P-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 LEU A 113
HIS A  57
THR A 156
TYR A 154
None
1.22A 5z85C-4nz0A:
undetectable
5z85N-4nz0A:
undetectable
5z85P-4nz0A:
undetectable
5z85C-4nz0A:
19.91
5z85N-4nz0A:
22.41
5z85P-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.21A 5z86A-4nz0A:
undetectable
5z86C-4nz0A:
undetectable
5z86P-4nz0A:
undetectable
5z86A-4nz0A:
22.41
5z86C-4nz0A:
19.91
5z86P-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.20A 5zcoA-4nz0A:
undetectable
5zcoC-4nz0A:
undetectable
5zcoP-4nz0A:
undetectable
5zcoA-4nz0A:
22.41
5zcoC-4nz0A:
19.91
5zcoP-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 LEU A 113
HIS A  57
THR A 156
TYR A 154
None
1.19A 5zcoC-4nz0A:
undetectable
5zcoN-4nz0A:
undetectable
5zcoP-4nz0A:
undetectable
5zcoC-4nz0A:
19.91
5zcoN-4nz0A:
22.41
5zcoP-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.21A 5zcpA-4nz0A:
undetectable
5zcpC-4nz0A:
undetectable
5zcpP-4nz0A:
undetectable
5zcpA-4nz0A:
22.41
5zcpC-4nz0A:
19.91
5zcpP-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A  57
THR A 156
TYR A 154
LEU A 113
None
1.19A 5zcqA-4nz0A:
undetectable
5zcqC-4nz0A:
undetectable
5zcqP-4nz0A:
undetectable
5zcqA-4nz0A:
22.41
5zcqC-4nz0A:
19.91
5zcqP-4nz0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 PHE A 256
TYR A  75
LEU A  83
SER A 208
None
1.22A 6a7pB-4nz0A:
undetectable
6a7pB-4nz0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 6 TYR A 285
ASP A 177
GLN A 155
VAL A 178
None
1.18A 6djzB-4nz0A:
undetectable
6djzB-4nz0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.19A 6fbnB-4nz0A:
undetectable
6fbnB-4nz0A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.16A 6fboA-4nz0A:
undetectable
6fboA-4nz0A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 8 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.14A 6fcdA-4nz0A:
undetectable
6fcdA-4nz0A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 4 ARG A 392
GLU A 387
GLU A 452
ARG A 456
None
1.01A 6fk2A-4nz0A:
undetectable
6fk2A-4nz0A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 4 ARG A 456
GLU A 452
GLU A 387
ARG A 392
None
0.89A 6fk2A-4nz0A:
undetectable
6fk2A-4nz0A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.15A 6g6rA-4nz0A:
undetectable
6g6rA-4nz0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
4 / 7 GLY A 290
LEU A 291
GLY A 356
TYR A 357
None
0.82A 6nm4A-4nz0A:
undetectable
6nm4A-4nz0A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)
4nz0 GENOME POLYPROTEIN
(Cardiovirus
A)
5 / 12 LEU A 251
ILE A 304
LEU A  82
PHE A 256
ASN A  87
None
1.31A 6qyaD-4nz0A:
undetectable
6qyaD-4nz0A:
21.79