SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 204
GLY A 332
LYS A 369
TYR A 374
 None
 1.34A 1gtiC-4nz6A:
undetectable		 1gtiC-4nz6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 204
GLY A 332
LYS A 369
TYR A 374
 None
 1.34A 1gtiF-4nz6A:
undetectable		 1gtiF-4nz6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 GLY A 148
LYS A 147
GLY A  99
HIS A  98
 None
 0.93A 1mf1A-4nz6A:
undetectable		 1mf1A-4nz6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.11A 1p7lC-4nz6A:
undetectable		 1p7lC-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.10A 1p7lD-4nz6A:
undetectable		 1p7lD-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.11A 1rg9A-4nz6A:
undetectable		 1rg9A-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.09A 1rg9B-4nz6A:
undetectable		 1rg9B-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.12A 1rg9C-4nz6A:
undetectable		 1rg9C-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.10A 1rg9D-4nz6A:
undetectable		 1rg9D-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLN A 293
LYS A 296
VAL A 298
 None
 0.90A 2jfaB-4nz6A:
undetectable		 2jfaB-4nz6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TRP A 390
THR A 393
TYR A 308
MET A 387
 None
 1.15A 3wipG-4nz6A:
undetectable
3wipH-4nz6A:
undetectable		 3wipG-4nz6A:
21.12
3wipH-4nz6A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 336
TYR A 267
GLU A 269
 None
 0.76A 4ryaA-4nz6A:
undetectable		 4ryaA-4nz6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 385
ASP A 383
ARG A 382
 None
EDO  A 401 (-4.4A)
None
 0.52A 4wq4B-4nz6A:
undetectable		 4wq4B-4nz6A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 VAL A 298
VAL A 301
VAL A 302
PHE A 210
LEU A 236
 None
 1.09A 5e4dB-4nz6A:
2.5		 5e4dB-4nz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASP A 146
HIS A 292
ILE A 294
TYR A 203
 None
 1.19A 5ih0A-4nz6A:
undetectable		 5ih0A-4nz6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 HIS A 177
PRO A 175
SER A 150
THR A 145
ASP A 115
 None
None
None
DLY  A 403 (-4.6A)
None
 1.27A 5t8sB-4nz6A:
undetectable		 5t8sB-4nz6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 205
GLY A 332
GLY A 330
VAL A 149
CYH A 268
 None
None
None
DLY  A 403 (-4.4A)
None
 1.15A 5uc1A-4nz6A:
undetectable		 5uc1A-4nz6A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 205
GLY A 332
GLY A 330
VAL A 149
CYH A 268
 None
None
None
DLY  A 403 (-4.4A)
None
 1.13A 5uc1B-4nz6A:
undetectable		 5uc1B-4nz6A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 243
PHE A 245
ASN A 233
ILE A 304
LEU A 314
 None
 1.16A 6b3aA-4nz6A:
undetectable		 6b3aA-4nz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A 239
HIS A 243
PHE A 245
 None
 0.89A 6esmA-4nz6A:
undetectable		 6esmA-4nz6A:
16.33