SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_A_DIFA1375_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	4nzd	INTERLEUKIN-21 RECEPTOR (Homo sapiens)	3 / 3	LEU A 179 TYR A 141 GLN A 140	None	0.70A	2wekA-4nzdA: undetectable	2wekA-4nzdA: 20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MEG_A_T27A561_1 (P66 REVERSE TRANSCRIPTASE)	4nzd	INTERLEUKIN-21 RECEPTOR (Homo sapiens)	5 / 12	LEU A 139 VAL A 109 VAL A 107 LEU A 166 TYR A 141	None	1.19A	3megA-4nzdA: undetectable	3megA-4nzdA: 15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQW_C_ACHC323_0 (ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI)	4nzd	INTERLEUKIN-21 RECEPTOR (Homo sapiens)	4 / 8	GLU A 170 TYR A 141 LEU A 179 PHE A 171	None	1.08A	3rqwC-4nzdA: undetectable 3rqwD-4nzdA: undetectable	3rqwC-4nzdA: 19.86 3rqwD-4nzdA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQW_J_ACHJ323_0 (ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI)	4nzd	INTERLEUKIN-21 RECEPTOR (Homo sapiens)	4 / 8	GLU A 170 TYR A 141 LEU A 179 PHE A 171	None	1.08A	3rqwF-4nzdA: undetectable 3rqwJ-4nzdA: undetectable	3rqwF-4nzdA: 19.86 3rqwJ-4nzdA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V81_A_NVPA901_1 (HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT)	4nzd	INTERLEUKIN-21 RECEPTOR (Homo sapiens)	4 / 8	LEU A 139 VAL A 107 LEU A 166 TYR A 141	None	1.03A	3v81A-4nzdA: undetectable	3v81A-4nzdA: 16.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2WEK_A_DIFA1375_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","4nzd","INTERLEUKIN-21 RECEPTOR","Homo sapiens",3,"LEU A 179;TYR A 141;GLN A 140","None","0.70A","2wekA-4nzdA:undetectable","2wekA-4nzdA:20.19"],["3MEG_A_T27A561_1","P66 REVERSE TRANSCRIPTASE","4nzd","INTERLEUKIN-21 RECEPTOR","Homo sapiens",5,"LEU A 139;VAL A 109;VAL A 107;LEU A 166;TYR A 141","None","1.19A","3megA-4nzdA:undetectable","3megA-4nzdA:15.79"],["3RQW_C_ACHC323_0","ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI","4nzd","INTERLEUKIN-21 RECEPTOR","Homo sapiens",4,"GLU A 170;TYR A 141;LEU A 179;PHE A 171","None","1.08A","3rqwC-4nzdA:undetectable;3rqwD-4nzdA:undetectable","3rqwC-4nzdA:19.86;3rqwD-4nzdA:19.86"],["3RQW_J_ACHJ323_0","ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI","4nzd","INTERLEUKIN-21 RECEPTOR","Homo sapiens",4,"GLU A 170;TYR A 141;LEU A 179;PHE A 171","None","1.08A","3rqwF-4nzdA:undetectable;3rqwJ-4nzdA:undetectable","3rqwF-4nzdA:19.86;3rqwJ-4nzdA:19.86"],["3V81_A_NVPA901_1","HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT","4nzd","INTERLEUKIN-21 RECEPTOR","Homo sapiens",4,"LEU A 139;VAL A 107;LEU A 166;TYR A 141","None","1.03A","3v81A-4nzdA:undetectable","3v81A-4nzdA:16.90"]]