SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		5 / 12 LEU A 239
LEU A 119
LEU A 120
GLY A 292
LEU A 265
 None
 1.25A 1g50B-4nzjA:
undetectable		 1g50B-4nzjA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		5 / 11 LEU A 239
LEU A 119
LEU A 120
GLY A 292
LEU A 265
 None
 1.25A 1g50C-4nzjA:
undetectable		 1g50C-4nzjA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 ASP A 238
ARG A 270
GLY A  86
GLY A 201
 None
 0.84A 1jr1B-4nzjA:
5.3		 1jr1B-4nzjA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 4 HIS A 423
ASP A 425
SER A 418
ASP A 422
 None
 1.47A 1n2xA-4nzjA:
undetectable		 1n2xA-4nzjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 ASP A 228
PHE A 232
GLY A 220
ASP A 209
 None
 0.98A 1rmtC-4nzjA:
undetectable		 1rmtC-4nzjA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		3 / 3 SER A  59
ASP A 400
CYH A 375
 None
 0.86A 2br4E-4nzjA:
undetectable		 2br4E-4nzjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		5 / 12 ARG A  37
PRO A  36
THR A  58
ILE A  84
LEU A  98
 None
 1.36A 3iv6C-4nzjA:
undetectable		 3iv6C-4nzjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		5 / 10 LEU A 197
ILE A 272
VAL A 237
VAL A 193
LEU A 204
 None
 1.24A 3ogpB-4nzjA:
undetectable		 3ogpB-4nzjA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 7 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.16A 4fevB-4nzjA:
undetectable		 4fevB-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 7 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.20A 4fevD-4nzjA:
undetectable		 4fevD-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 7 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.20A 4fevF-4nzjA:
undetectable		 4fevF-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 7 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.17A 4fewB-4nzjA:
undetectable		 4fewB-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.20A 4fewD-4nzjA:
undetectable		 4fewD-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.21A 4fewF-4nzjA:
undetectable		 4fewF-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 SER A 418
GLU A 331
GLY A 412
ARG A 413
 None
 0.82A 4fgzA-4nzjA:
undetectable
4fgzB-4nzjA:
undetectable		 4fgzA-4nzjA:
20.61
4fgzB-4nzjA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.17A 4gkhB-4nzjA:
undetectable		 4gkhB-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.13A 4gkhD-4nzjA:
undetectable		 4gkhD-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 7 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.22A 4gkhG-4nzjA:
2.4		 4gkhG-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 6 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.19A 4gkhJ-4nzjA:
undetectable		 4gkhJ-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 ASP A 243
ASP A 165
ASP A 340
ASN A 128
 GOL  A 600 (-3.6A)
GOL  A 600 (-3.2A)
None
None
 1.18A 4gkiA-4nzjA:
undetectable		 4gkiA-4nzjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		3 / 3 ASP A 243
TYR A 207
TRP A 279
 GOL  A 600 (-3.6A)
GOL  A 600 (-4.3A)
None
 1.06A 4p7nA-4nzjA:
5.8		 4p7nA-4nzjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 8 HIS A 317
ASP A 301
PRO A 341
TRP A 285
 None
 1.09A 4uhxA-4nzjA:
undetectable		 4uhxA-4nzjA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		3 / 3 ALA A 415
TRP A 427
VAL A 428
 None
 0.34A 4w9nC-4nzjA:
undetectable		 4w9nC-4nzjA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 6 GLY A  92
ASP A  93
ARG A 114
GLY A 116
 None
 0.87A 5cdnR-4nzjA:
undetectable
5cdnS-4nzjA:
undetectable		 5cdnR-4nzjA:
20.08
5cdnS-4nzjA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 6 GLY A  92
ASP A  93
ARG A 114
GLY A 116
 None
 0.88A 5cdnC-4nzjA:
undetectable
5cdnD-4nzjA:
undetectable		 5cdnC-4nzjA:
20.08
5cdnD-4nzjA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		3 / 3 ILE A  43
MET A  88
ASP A  93
 None
 0.83A 5h2uA-4nzjA:
2.0		 5h2uA-4nzjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 6 ILE A 305
GLY A 384
ASN A 385
ILE A 302
 None
 0.94A 5j4nB-4nzjA:
undetectable		 5j4nB-4nzjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		5 / 12 ILE A  56
PHE A  54
ILE A  84
LEU A  77
SER A  40
 None
 1.05A 5km9B-4nzjA:
undetectable		 5km9B-4nzjA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		5 / 12 ILE A  56
PHE A  54
ILE A  84
LEU A  77
VAL A  96
 None
 1.16A 5km9B-4nzjA:
undetectable		 5km9B-4nzjA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		4 / 7 GLN A 281
GLY A 300
GLN A 414
ASP A 309
 None
 1.00A 5vlmE-4nzjA:
undetectable		 5vlmE-4nzjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		3 / 3 ASN A 339
VAL A 273
HIS A 294
 None
 0.86A 6a5yD-4nzjA:
undetectable		 6a5yD-4nzjA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4nzj PUTATIVE
ALPHA-GALACTOSIDASE
(Bacteroides
fragilis) 		3 / 3 LEU A 265
ASN A 163
LEU A 295
 None
 0.76A 6exiD-4nzjA:
2.6		 6exiD-4nzjA:
12.14