SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nzm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 7 ARG A 262
ASP A 309
ASP A 321
TYR A 250
 0EJ  A 402 (-3.0A)
MG  A 404 ( 2.9A)
MG  A 403 (-2.0A)
None
 1.15A 1ceaB-4nzmA:
undetectable		 1ceaB-4nzmA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 7 ARG A 262
ASP A 309
ASP A 321
TYR A 250
 0EJ  A 402 (-3.0A)
MG  A 404 ( 2.9A)
MG  A 403 (-2.0A)
None
 1.11A 1cebA-4nzmA:
undetectable		 1cebA-4nzmA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 4 THR A 242
LEU A 311
LEU A 148
GLN A 142
 None
ANP  A 401 (-4.7A)
None
None
 1.14A 1fbmA-4nzmA:
undetectable		 1fbmA-4nzmA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 6 PRO A 265
GLU A 237
GLN A 209
VAL A 185
 ANP  A 401 ( 4.8A)
ANP  A 401 (-3.6A)
None
ANP  A 401 (-4.9A)
 1.31A 1l2iB-4nzmA:
undetectable		 1l2iB-4nzmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		3 / 3 SER A 264
VAL A 196
LEU A 211
 ANP  A 401 (-3.0A)
None
ANP  A 401 (-4.9A)
 0.73A 1yajG-4nzmA:
undetectable		 1yajG-4nzmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		5 / 12 PRO A 119
ALA A 300
LEU A 299
THR A 251
ILE A 122
 None
 1.22A 2jjpA-4nzmA:
undetectable		 2jjpA-4nzmA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 7 GLY A 307
THR A 251
CYH A 298
GLN A 303
 None
 1.16A 2qx4A-4nzmA:
3.2
2qx4B-4nzmA:
3.6		 2qx4A-4nzmA:
19.76
2qx4B-4nzmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		3 / 3 TYR A 234
ARG A 156
SER A 233
 None
 1.15A 4dr2I-4nzmA:
undetectable
4dr2J-4nzmA:
undetectable		 4dr2I-4nzmA:
16.92
4dr2J-4nzmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 8 SER A  99
CYH A  49
PHE A  78
TRP A  91
 None
 1.22A 4j7uD-4nzmA:
3.1		 4j7uD-4nzmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 8 ILE A 131
ILE A 140
ALA A 300
VAL A 322
 None
 0.65A 4jltA-4nzmA:
undetectable		 4jltA-4nzmA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		3 / 3 TYR A 250
ARG A 262
LYS A 248
 None
0EJ  A 402 (-3.0A)
0EJ  A 402 ( 2.8A)
 1.40A 4wq5B-4nzmA:
undetectable		 4wq5B-4nzmA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 7 ARG A 281
TYR A 335
GLU A 260
TYR A 334
 None
 1.16A 4zz8A-4nzmA:
undetectable		 4zz8A-4nzmA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 6 ILE A  44
PHE A  70
PHE A 120
THR A 304
 None
 1.25A 5g08A-4nzmA:
undetectable		 5g08A-4nzmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 6 SER A 331
HIS A 258
ARG A 281
GLU A 260
 None
 1.48A 5x7pB-4nzmA:
undetectable		 5x7pB-4nzmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 6 SER A 331
HIS A 258
ARG A 281
GLU A 260
 None
 1.44A 5x7qB-4nzmA:
undetectable		 5x7qB-4nzmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens) 		4 / 6 SER A 331
HIS A 258
ARG A 281
GLU A 260
 None
 1.48A 5x7rB-4nzmA:
undetectable		 5x7rB-4nzmA:
14.86