SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A 250
ASN A 251
LEU A 253
GLY A 254
LEU A 187
 None
 1.18A 1gs4A-4nzpA:
undetectable		 1gs4A-4nzpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 GLY A 283
LEU A  92
LEU A 247
LEU A 187
LEU A 233
 None
 1.03A 1mx1F-4nzpA:
undetectable		 1mx1F-4nzpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A 250
ASN A 251
LEU A 253
GLY A 254
LEU A 187
 None
 1.10A 2oz7A-4nzpA:
undetectable		 2oz7A-4nzpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.28A 2q7iA-4nzpA:
undetectable		 2q7iA-4nzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.28A 2q7kA-4nzpA:
undetectable		 2q7kA-4nzpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.29A 2q7lA-4nzpA:
undetectable		 2q7lA-4nzpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		4 / 4 ARG A 344
GLY A 358
GLU A 360
SER A 221
 None
 1.37A 2xctS-4nzpA:
undetectable
2xctU-4nzpA:
undetectable		 2xctS-4nzpA:
21.81
2xctU-4nzpA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.30A 2yloA-4nzpA:
undetectable		 2yloA-4nzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLQ_A_TESA1921_1
(ANDROGEN RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 11 LEU A 247
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.43A 2ylqA-4nzpA:
undetectable		 2ylqA-4nzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A 247
LEU A 250
ASN A 251
LEU A 253
LEU A 347
 None
 0.89A 3d90B-4nzpA:
undetectable		 3d90B-4nzpA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 GLY A 121
ALA A  11
PHE A  36
THR A  37
ALA A  38
 None
 1.09A 3sugA-4nzpA:
undetectable		 3sugA-4nzpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		6 / 12 LEU A 247
LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.33A 3zqtA-4nzpA:
undetectable		 3zqtA-4nzpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		3 / 3 GLU A 133
TYR A 136
SER A 119
 None
 1.00A 4at0A-4nzpA:
undetectable		 4at0A-4nzpA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A  68
ILE A  40
ALA A 103
ALA A  11
ALA A  38
 None
 0.89A 4enhA-4nzpA:
undetectable		 4enhA-4nzpA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		4 / 6 LEU A 226
GLU A 225
ASN A 237
ILE A 236
 None
 0.91A 4ww7A-4nzpA:
undetectable		 4ww7A-4nzpA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		4 / 7 VAL A  33
ILE A 146
HIS A 167
TRP A  24
 None
 1.04A 4xo7B-4nzpA:
undetectable		 4xo7B-4nzpA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 10 GLY A 282
THR A 280
PHE A 228
LEU A 287
LEU A  92
 None
 1.19A 5fhzC-4nzpA:
4.1		 5fhzC-4nzpA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		4 / 8 TRP A 152
TRP A  24
GLU A 151
HIS A 120
 None
 1.34A 5hqaA-4nzpA:
undetectable		 5hqaA-4nzpA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		3 / 3 LYS A 215
ASP A 216
ARG A 261
 None
 0.81A 5jwaA-4nzpA:
undetectable
5jwaH-4nzpA:
2.8		 5jwaA-4nzpA:
22.45
5jwaH-4nzpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4nzp ARGININOSUCCINATE
SYNTHASE
(Campylobacter
jejuni) 		5 / 12 LEU A 250
ASN A 251
LEU A 253
GLY A 254
LEU A 347
 None
 0.90A 5uc1B-4nzpA:
undetectable		 5uc1B-4nzpA:
12.88