SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		3 / 3 ARG M 457
GLY H  31
ASP H  31
 None
 0.57A 1kf6A-4nzrM:
undetectable
1kf6B-4nzrM:
undetectable		 1kf6A-4nzrM:
21.86
1kf6B-4nzrM:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 8 TYR M 233
GLU M 311
SER M 291
TYR M 315
 None
 1.33A 1nx9A-4nzrM:
2.8		 1nx9A-4nzrM:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 8 TYR M 233
GLU M 311
SER M 291
TYR M 315
 None
 1.31A 1nx9B-4nzrM:
undetectable		 1nx9B-4nzrM:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 8 TYR M 233
GLU M 311
SER M 291
TYR M 315
 None
 1.34A 1nx9C-4nzrM:
3.2		 1nx9C-4nzrM:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		3 / 3 ASP H  31
ASP H  27
ASN M 452
 None
 0.85A 2bm9D-4nzrH:
undetectable		 2bm9D-4nzrH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 LEU M 266
ALA M 248
GLY M 275
VAL M 290
ILE M 268
 None
 1.21A 2o4lA-4nzrM:
undetectable		 2o4lA-4nzrM:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 6 LEU M 266
LEU M 244
ILE M 268
ARG M 269
 None
None
None
GOL  M 501 (-3.9A)
 0.93A 2rlfC-4nzrM:
undetectable
2rlfD-4nzrM:
undetectable		 2rlfC-4nzrM:
7.27
2rlfD-4nzrM:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4nzr PGT135 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY H  31
TYR H  32
GLY H  31
PRO H 100
ARG H  96
 None
 1.34A 2y7kC-4nzrH:
undetectable		 2y7kC-4nzrH:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 4 SER M 316
GLY M 294
GLY M 298
GLY M 273
 None
 0.90A 3bogB-4nzrM:
undetectable
3bogD-4nzrM:
undetectable		 3bogB-4nzrM:
undetectable
3bogD-4nzrM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 LEU M 271
ILE M 251
SER M 252
LYS M 255
LEU M 283
 None
 1.18A 3cd2A-4nzrM:
undetectable		 3cd2A-4nzrM:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCD_B_LNRB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 TYR M 163
ASN M 165
ARG M 167
TYR M 338
ASP M 339
 None
 1.43A 3hcdB-4nzrM:
2.7		 3hcdB-4nzrM:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 GLY M 270
ASP M 247
ILE M 268
ASP M 295
LEU M 271
 None
 1.32A 3iv6B-4nzrM:
2.4		 3iv6B-4nzrM:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 8 ALA M 149
GLN M 174
LEU M 155
TYR M 157
SER M 232
 None
 1.39A 3qj7A-4nzrM:
undetectable
3qj7D-4nzrM:
undetectable		 3qj7A-4nzrM:
22.80
3qj7D-4nzrM:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 TYR M 296
GLY M 298
VAL M 329
ALA M 248
ASN M 300
 None
 1.26A 3qowA-4nzrM:
undetectable		 3qowA-4nzrM:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		3 / 3 ASP M 188
GLY H 169
TYR M 187
 None
 0.70A 3w9tC-4nzrM:
undetectable		 3w9tC-4nzrM:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		3 / 3 ASP M 188
GLY H 169
TYR M 187
 None
 0.70A 3w9tG-4nzrM:
undetectable		 3w9tG-4nzrM:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		4 / 7 GLU M 427
ILE M 449
TYR H  32
HIS H  95
 None
 0.71A 4a97D-4nzrM:
undetectable		 4a97D-4nzrM:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		4 / 7 GLU M 427
ILE M 449
TYR H  32
HIS H  95
 None
 0.72A 4a97H-4nzrM:
undetectable		 4a97H-4nzrM:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		4 / 6 GLU M 427
ILE M 449
TYR H  32
HIS H  95
 None
 0.80A 4a97I-4nzrM:
undetectable		 4a97I-4nzrM:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 6 ASN M 442
TYR M 377
TYR M 394
LEU M 423
 None
 1.39A 4f8yA-4nzrM:
1.8
4f8yB-4nzrM:
1.9		 4f8yA-4nzrM:
17.79
4f8yB-4nzrM:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 7 TYR M 377
TYR M 394
LEU M 423
ASN M 442
 None
 1.38A 4f8yC-4nzrM:
undetectable
4f8yD-4nzrM:
undetectable		 4f8yC-4nzrM:
17.79
4f8yD-4nzrM:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		6 / 9 LEU M 278
GLY M 270
ALA M 248
ASP M 250
ILE M 267
ILE M 251
 None
None
None
None
GOL  M 501 ( 4.3A)
None
 1.25A 4rvjB-4nzrM:
undetectable		 4rvjB-4nzrM:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		6 / 9 LEU M 278
GLY M 270
ALA M 248
ASP M 250
ILE M 267
ILE M 251
 None
None
None
None
GOL  M 501 ( 4.3A)
None
 1.27A 4rvjD-4nzrM:
undetectable		 4rvjD-4nzrM:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 LEU M 292
LEU M 271
ILE M 268
LEU M 266
ILE M 246
 None
 0.73A 4y0rA-4nzrM:
undetectable		 4y0rA-4nzrM:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 6 ASN M 183
ASP M 339
THR M 137
PRO M 138
 None
 1.05A 4yoaA-4nzrM:
undetectable		 4yoaA-4nzrM:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 6 ILE M 172
PHE M 197
ILE M 337
GLU M 313
 None
 1.09A 4zzcA-4nzrM:
undetectable
4zzcB-4nzrM:
undetectable		 4zzcA-4nzrM:
22.70
4zzcB-4nzrM:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 6 ILE M 172
PHE M 197
ILE M 337
GLU M 313
 None
 1.07A 4zzcB-4nzrM:
undetectable
4zzcC-4nzrM:
undetectable		 4zzcB-4nzrM:
22.70
4zzcC-4nzrM:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 11 GLY M 199
PRO M 228
ALA M 223
PHE M 222
TYR M 221
 None
 1.39A 5c8tB-4nzrM:
undetectable		 5c8tB-4nzrM:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 11 GLY M 199
PRO M 228
ALA M 224
PHE M 222
TYR M 221
 None
 1.19A 5c8tB-4nzrM:
undetectable		 5c8tB-4nzrM:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 7 GLU M 441
GLY M 392
GLY M 388
TYR M 377
 None
 0.98A 5e26A-4nzrM:
undetectable
5e26B-4nzrM:
undetectable		 5e26A-4nzrM:
20.75
5e26B-4nzrM:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 LEU M 169
LEU M 292
ILE M 305
THR M 243
LEU M 281
 None
 1.18A 5ienB-4nzrM:
undetectable		 5ienB-4nzrM:
16.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4nzr PGT135 HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H 112
ALA H 114
PHE H 148
LEU H 178
 None
 0.41A 5mthA-4nzrH:
24.6		 5mthA-4nzrH:
51.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 SER M 276
ASN M 300
SER M 272
GLY M 273
THR M 297
 None
 1.44A 5oj0A-4nzrM:
2.1		 5oj0A-4nzrM:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 LEU M 266
ALA M 248
GLY M 275
VAL M 290
ILE M 268
 None
 1.19A 6difA-4nzrM:
undetectable		 6difA-4nzrM:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		4 / 6 LEU M 169
TYR M 293
ASP M 339
GLU M 313
 None
GOL  M 501 ( 2.8A)
None
None
 1.42A 6djzC-4nzrM:
undetectable		 6djzC-4nzrM:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		5 / 8 ASP M 408
ARG M 457
GLU M 453
ASP H  31
GLU H  31
 None
 1.41A 6mn4A-4nzrM:
undetectable		 6mn4A-4nzrM:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium) 		4 / 7 ARG M 457
GLU M 453
ASP H  31
GLU H  31
 None
 1.42A 6mn4F-4nzrM:
undetectable		 6mn4F-4nzrM:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4nzr PROTEIN M TD
(Mycoplasma
genitalium) 		5 / 12 LEU M 330
GLY M 324
PHE M 325
ASN M 300
ILE M 395
 None
 1.08A 6qxsB-4nzrM:
undetectable		 6qxsB-4nzrM:
20.61