SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A 381
GLY A  91
GLY A 356
ILE A 352
ALA A  96
 None
 0.91A 1nv8B-4nzsA:
undetectable		 1nv8B-4nzsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 7 MET A 158
ILE A 292
VAL A 328
PRO A 294
 None
 1.06A 1rxcC-4nzsA:
undetectable		 1rxcC-4nzsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A 381
GLY A  91
GLY A 356
ILE A 352
ALA A  96
 None
 0.88A 1sg9B-4nzsA:
undetectable		 1sg9B-4nzsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A 315
LEU A 332
GLY A 333
VAL A 328
ALA A 327
 None
 1.14A 1tlsA-4nzsA:
undetectable		 1tlsA-4nzsA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A 381
GLY A  91
GLY A 356
ILE A 352
ALA A  96
 None
 0.97A 1vq1B-4nzsA:
undetectable		 1vq1B-4nzsA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 GLY A 116
GLY A 356
GLY A  93
ALA A  96
ASN A 318
 None
 1.01A 2dpmA-4nzsA:
undetectable		 2dpmA-4nzsA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 7 ALA A 354
ASN A  56
PRO A  27
ALA A 117
 None
 1.05A 2ejfA-4nzsA:
undetectable		 2ejfA-4nzsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 6 SER A 347
LEU A 348
SER A 183
GLU A 316
 None
 1.06A 2j2pE-4nzsA:
undetectable
2j2pF-4nzsA:
undetectable		 2j2pE-4nzsA:
21.97
2j2pF-4nzsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 4 LEU A 232
THR A 230
ILE A 346
HIS A 184
 None
 1.39A 2jfaB-4nzsA:
undetectable		 2jfaB-4nzsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		3 / 3 ARG A 269
THR A 109
VAL A 111
 None
 0.98A 2q64A-4nzsA:
undetectable		 2q64A-4nzsA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		3 / 3 ARG A 269
THR A 109
VAL A 111
 None
 0.99A 2qakA-4nzsA:
undetectable		 2qakA-4nzsA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 7 THR A 360
GLY A 356
LEU A 277
PHE A 391
 None
 0.99A 2vl2B-4nzsA:
undetectable		 2vl2B-4nzsA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 7 ALA A 354
ASN A  56
PRO A  27
ALA A 117
 None
 1.05A 2zgwA-4nzsA:
undetectable		 2zgwA-4nzsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 6 ALA A 354
ASN A  56
PRO A  27
ALA A 117
 None
 1.03A 2zgwB-4nzsA:
undetectable		 2zgwB-4nzsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 7 GLY A 343
GLY A 345
GLU A 319
ALA A 187
 None
 0.83A 3fpjB-4nzsA:
undetectable		 3fpjB-4nzsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 GLY A 353
THR A 355
ASP A  64
ILE A  58
THR A  60
 None
 1.02A 3iv6A-4nzsA:
undetectable		 3iv6A-4nzsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A 292
GLY A 291
ALA A 320
ALA A 166
VAL A 165
 None
 1.01A 3jb2A-4nzsA:
undetectable		 3jb2A-4nzsA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 GLY A 116
GLY A  93
VAL A  86
ALA A  71
LEU A 358
 None
 1.11A 3mteA-4nzsA:
undetectable		 3mteA-4nzsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A  97
ALA A 100
ALA A 101
ALA A 112
VAL A 377
 None
 1.20A 3uvvB-4nzsA:
undetectable		 3uvvB-4nzsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 LEU A 277
THR A 109
ILE A 104
ALA A 357
VAL A  49
 None
 1.18A 3vw1D-4nzsA:
undetectable		 3vw1D-4nzsA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 7 ALA A 257
PHE A  54
ALA A 117
THR A  13
 None
 0.83A 4du2A-4nzsA:
undetectable		 4du2A-4nzsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 7 ALA A 257
PHE A  54
ALA A 117
THR A  13
 None
 0.74A 4du2B-4nzsA:
undetectable		 4du2B-4nzsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 LEU A 312
ILE A 315
ALA A 389
ALA A 297
GLY A 293
 None
 0.96A 4enhA-4nzsA:
undetectable		 4enhA-4nzsA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 GLY A  75
GLY A  76
VAL A  11
PHE A  54
ILE A 113
 None
 1.23A 4fglA-4nzsA:
undetectable
4fglB-4nzsA:
undetectable		 4fglA-4nzsA:
20.00
4fglB-4nzsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A 315
LEU A 332
GLY A 333
VAL A 328
ALA A 327
 None
 1.21A 4foxD-4nzsA:
undetectable		 4foxD-4nzsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A 315
LEU A 332
GLY A 333
VAL A 328
ALA A 327
 None
 1.20A 4fqsA-4nzsA:
undetectable		 4fqsA-4nzsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 12 ILE A 315
LEU A 332
GLY A 333
VAL A 328
ALA A 327
 None
 1.19A 4fqsB-4nzsA:
undetectable		 4fqsB-4nzsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 11 GLY A 116
GLY A  55
ALA A 117
GLU A 118
GLN A  59
 None
 1.03A 4l8fB-4nzsA:
undetectable		 4l8fB-4nzsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 11 GLY A 116
GLY A  55
ALA A 117
GLU A 118
GLN A  59
 None
 0.89A 4l8fD-4nzsA:
undetectable		 4l8fD-4nzsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		3 / 3 GLU A   4
ILE A 390
ALA A 101
 None
 0.59A 4wnwB-4nzsA:
undetectable		 4wnwB-4nzsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		3 / 3 ASP A 313
ARG A 373
TYR A 374
 None
 0.58A 5a7mA-4nzsA:
undetectable		 5a7mA-4nzsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		3 / 3 ASP A 313
ARG A 373
TYR A 374
 None
 0.58A 5a7mB-4nzsA:
undetectable		 5a7mB-4nzsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 8 VAL A  34
ALA A 257
GLY A 114
GLY A  55
 None
 0.83A 5e26C-4nzsA:
undetectable
5e26D-4nzsA:
undetectable		 5e26C-4nzsA:
20.86
5e26D-4nzsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 8 VAL A  34
ALA A 257
GLY A 114
GLY A  93
 None
 0.66A 5e26C-4nzsA:
undetectable
5e26D-4nzsA:
undetectable		 5e26C-4nzsA:
20.86
5e26D-4nzsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 9 ILE A  15
GLY A 349
GLY A 250
LEU A  22
ALA A 254
 None
 0.91A 5o96A-4nzsA:
undetectable
5o96B-4nzsA:
undetectable		 5o96A-4nzsA:
20.40
5o96B-4nzsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		4 / 4 ALA A 322
ALA A 325
ALA A 179
ALA A 180
 None
 0.86A 6gtqA-4nzsA:
undetectable
6gtqB-4nzsA:
undetectable		 6gtqA-4nzsA:
18.58
6gtqB-4nzsA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4nzs BETA-KETOTHIOLASE
BKTB
(Cupriavidus
necator) 		5 / 11 ALA A  42
LEU A  39
VAL A  77
THR A 109
ALA A 112
 None
 1.04A 6h1lB-4nzsA:
undetectable		 6h1lB-4nzsA:
21.92