SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4nzu 13PL LIGHT CHAIN
(Homo
sapiens) 		5 / 12 HIS H  35
LEU H   4
GLY H 104
VAL H   2
ALA H   1
 None
 1.07A 1tlsA-4nzuH:
undetectable		 1tlsA-4nzuH:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4nzu 13PL LIGHT CHAIN
(Homo
sapiens) 		4 / 7 SER H  55
SER H  56
SER H  52
ASN H  53
 None
 1.02A 2cmlA-4nzuH:
undetectable		 2cmlA-4nzuH:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4nzu 13PL LIGHT CHAIN
(Homo
sapiens) 		4 / 8 SER H  55
SER H  56
SER H  52
ASN H  53
 None
 1.00A 2cmlB-4nzuH:
undetectable		 2cmlB-4nzuH:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4nzu 13PL LIGHT CHAIN
(Homo
sapiens) 		4 / 8 SER H  55
SER H  56
SER H  52
ASN H  53
 None
 1.03A 2cmlC-4nzuH:
undetectable		 2cmlC-4nzuH:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4nzu 13PL LIGHT CHAIN
(Homo
sapiens) 		4 / 8 SER H  55
SER H  56
SER H  52
ASN H  53
 None
 1.10A 2cmlD-4nzuH:
undetectable		 2cmlD-4nzuH:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4nzu 13PL LIGHT CHAIN
(Homo
sapiens) 		4 / 5 ARG H  19
MET H  82
THR H  17
LEU H  82
 None
 1.28A 5z86J-4nzuH:
undetectable		 5z86J-4nzuH:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4nzu 13PL LIGHT CHAIN
(Homo
sapiens) 		4 / 5 ARG H  19
MET H  82
THR H  17
LEU H  82
 None
 1.15A 6nknW-4nzuH:
undetectable		 6nknW-4nzuH:
12.84