SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		4 / 5 LEU A   6
PRO A 122
ILE A  79
ARG A  74
 None
PEG  A 307 (-4.0A)
None
PEG  A 304 ( 3.8A)
 0.88A 2qd4A-4nzyA:
undetectable		 2qd4A-4nzyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		3 / 3 LYS A 147
ARG A 144
ASP A  92
 None
 1.11A 3o7wA-4nzyA:
undetectable		 3o7wA-4nzyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A  94
LYS A 121
TYR A  99
TYR A 116
 None
 1.42A 3pmzE-4nzyA:
0.0		 3pmzE-4nzyA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		5 / 11 TYR A  35
ILE A  88
PHE A  87
THR A  97
GLU A  10
 EPE  A 301 (-4.2A)
None
None
EDO  A 310 ( 4.9A)
None
 1.30A 3qelA-4nzyA:
3.6
3qelB-4nzyA:
undetectable		 3qelA-4nzyA:
19.57
3qelB-4nzyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A  13
ASN A  40
ARG A  93
GLY A 152
 EDO  A 310 ( 4.5A)
PEG  A 304 ( 4.9A)
EDO  A 310 (-3.5A)
None
 1.03A 4af0A-4nzyA:
undetectable		 4af0A-4nzyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		4 / 5 LEU A   6
PRO A 122
ILE A  79
ARG A  74
 None
PEG  A 307 (-4.0A)
None
PEG  A 304 ( 3.8A)
 0.93A 4klrA-4nzyA:
2.4		 4klrA-4nzyA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  98
ILE A  95
THR A 125
VAL A  89
TYR A 176
 None
None
PEG  A 307 (-3.5A)
None
None
 1.08A 4km2A-4nzyA:
undetectable		 4km2A-4nzyA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		4 / 7 GLU A  10
ASP A 102
ALA A 100
TYR A  99
 None
 1.11A 4zz8A-4nzyA:
undetectable		 4zz8A-4nzyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4nzy PROBABLE THYMIDYLATE
KINASE
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A  35
ILE A  88
PHE A  87
THR A  97
GLU A  10
 EPE  A 301 (-4.2A)
None
None
EDO  A 310 ( 4.9A)
None
 1.30A 5ewjC-4nzyA:
3.9
5ewjD-4nzyA:
2.2		 5ewjC-4nzyA:
19.57
5ewjD-4nzyA:
21.25