SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		3 / 3 TRP A 394
VAL A 388
TRP A 412
 None
 1.30A 1c4dC-4o01A:
undetectable
1c4dD-4o01A:
undetectable		 1c4dC-4o01A:
4.05
1c4dD-4o01A:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 8 ASP A 171
VAL A 173
HIS A 291
GLY A 169
 None
 0.94A 1ekjA-4o01A:
undetectable
1ekjB-4o01A:
undetectable		 1ekjA-4o01A:
19.35
1ekjB-4o01A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 LEU A 273
PHE A 170
ALA A 225
GLY A  39
LEU A 253
 None
 1.09A 1fe2A-4o01A:
undetectable		 1fe2A-4o01A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 6 HIS A 116
LEU A  89
LEU A  97
PRO A  94
 None
 1.31A 1hz4A-4o01A:
undetectable		 1hz4A-4o01A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 8 ASP A 207
TYR A 176
GLY A 184
PRO A 204
 LBV  A 600 (-3.4A)
None
None
None
 0.83A 2ys6A-4o01A:
undetectable		 2ys6A-4o01A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		5 / 12 ILE A 287
LEU A 311
GLN A 315
VAL A 275
THR A 163
 None
 1.10A 3ix9B-4o01A:
undetectable		 3ix9B-4o01A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 7 GLU A 320
VAL A 316
LEU A 312
LEU A 283
 None
 0.96A 3qeoB-4o01A:
undetectable		 3qeoB-4o01A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		3 / 3 GLU A 381
GLY A 380
SER A 421
 None
 0.71A 4b53B-4o01A:
undetectable		 4b53B-4o01A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 7 ASP A 300
THR A 303
ARG A 100
SER A 112
 None
 1.49A 4o4dA-4o01A:
undetectable		 4o4dA-4o01A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		3 / 3 ASP A 207
LEU A 463
GLY A 464
 LBV  A 600 (-3.4A)
None
None
 0.55A 4xmfA-4o01A:
undetectable		 4xmfA-4o01A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 5 LEU A 438
ALA A 427
LEU A 426
LEU A 395
 None
 0.85A 5vkqA-4o01A:
undetectable
5vkqD-4o01A:
undetectable		 5vkqA-4o01A:
15.39
5vkqD-4o01A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 5 LEU A 395
LEU A 438
ALA A 427
LEU A 426
 None
 0.86A 5vkqA-4o01A:
undetectable
5vkqB-4o01A:
undetectable		 5vkqA-4o01A:
15.39
5vkqB-4o01A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 5 LEU A 395
LEU A 438
ALA A 427
LEU A 426
 None
 0.82A 5vkqB-4o01A:
undetectable
5vkqC-4o01A:
undetectable		 5vkqB-4o01A:
15.39
5vkqC-4o01A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		4 / 5 LEU A 395
LEU A 438
ALA A 427
LEU A 426
 None
 0.88A 5vkqC-4o01A:
undetectable
5vkqD-4o01A:
undetectable		 5vkqC-4o01A:
15.39
5vkqD-4o01A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4o01 BACTERIOPHYTOCHROME
(Deinococcus
radiodurans) 		3 / 3 ARG A 442
PHE A 327
ARG A 364
 None
 1.24A 5y9yA-4o01A:
undetectable		 5y9yA-4o01A:
22.54