SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 ASP A  78
THR A 112
PHE A 116
GLY A  90
ALA A  79
 None
 1.09A 1nw5A-4o0eA:
undetectable		 1nw5A-4o0eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 11 GLY A 188
SER A  67
ALA A 105
VAL A  95
ILE A  98
 None
 1.15A 2nnhA-4o0eA:
undetectable		 2nnhA-4o0eA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		6 / 12 GLY A  10
ILE A 189
GLY A 222
ILE A 225
PRO A 201
VAL A 186
 None
 1.46A 2nnkB-4o0eA:
undetectable		 2nnkB-4o0eA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 LEU A 233
THR A 218
GLY A 264
GLY A 263
THR A 279
 None
 1.09A 2uvnA-4o0eA:
undetectable		 2uvnA-4o0eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 11 THR A 219
THR A 184
ALA A  79
GLY A   9
SER A 217
 None
 1.18A 3mg0N-4o0eA:
3.1		 3mg0N-4o0eA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 LEU A 166
GLY A   9
HIS A   8
ALA A  54
ASN A  62
 None
 1.26A 3tm4A-4o0eA:
undetectable		 3tm4A-4o0eA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 LEU A 166
GLY A   9
HIS A   8
ALA A  54
ASN A  62
 None
 1.24A 3tm4B-4o0eA:
undetectable		 3tm4B-4o0eA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 GLY A 167
GLY A 220
VAL A 169
THR A 168
VAL A  68
 None
 1.08A 4f84A-4o0eA:
undetectable		 4f84A-4o0eA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 GLY A 207
ARG A 232
ILE A  81
ALA A 183
ASP A  83
 None
 1.17A 4kicA-4o0eA:
undetectable		 4kicA-4o0eA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 MET A 193
GLY A 188
SER A  93
ALA A  63
GLU A  56
 None
 1.41A 4ymgA-4o0eA:
undetectable		 4ymgA-4o0eA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 ALA A  47
ALA A  44
VAL A 180
LEU A  38
GLY A  41
 None
 1.39A 5igpA-4o0eA:
undetectable		 5igpA-4o0eA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 10 ALA A 183
THR A 184
ALA A  89
GLY A  90
ALA A 105
 None
 1.13A 5lf3H-4o0eA:
undetectable
5lf3I-4o0eA:
2.8		 5lf3H-4o0eA:
22.04
5lf3I-4o0eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 10 ALA A 183
THR A 184
ALA A  89
GLY A  90
ALA A 105
 None
 1.14A 5lf3V-4o0eA:
undetectable
5lf3W-4o0eA:
2.9		 5lf3V-4o0eA:
22.04
5lf3W-4o0eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 11 ALA A 183
THR A 184
ALA A  89
GLY A  90
ALA A 105
 None
 1.12A 5lf7H-4o0eA:
undetectable
5lf7I-4o0eA:
2.9		 5lf7H-4o0eA:
22.04
5lf7I-4o0eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 11 ALA A 183
THR A 184
ALA A  89
GLY A  90
ALA A 105
 None
 1.11A 5lf7V-4o0eA:
undetectable
5lf7W-4o0eA:
3.0		 5lf7V-4o0eA:
22.04
5lf7W-4o0eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 VAL A  48
ALA A  54
PRO A   3
ALA A  51
GLY A  50
 None
 1.34A 5tzoC-4o0eA:
undetectable		 5tzoC-4o0eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens) 		5 / 12 GLY A 207
ASP A 199
VAL A 228
GLY A 263
GLY A 264
 None
 0.73A 6dj1A-4o0eA:
undetectable		 6dj1A-4o0eA:
13.67