SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE A  32
LEU A 208
PHE A  29
LEU A  37
ILE A 223
 None
 0.88A 1cd2A-4o0mA:
2.2		 1cd2A-4o0mA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 10 SER A 282
PHE A 411
ALA A 286
LEU A 440
LEU A 297
 None
 1.01A 2bxqA-4o0mA:
undetectable		 2bxqA-4o0mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 11 PHE A 152
GLU A 198
ILE A 145
ILE A 128
PHE A  77
 None
 1.14A 2dg9A-4o0mA:
undetectable		 2dg9A-4o0mA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		4 / 6 VAL A 206
ILE A  32
HIS A 231
LEU A 224
 None
 0.81A 3hegA-4o0mA:
undetectable		 3hegA-4o0mA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		4 / 8 THR A  43
LEU A  37
SER A  33
HIS A 231
 None
 1.16A 3kp2A-4o0mA:
undetectable
3kp2B-4o0mA:
undetectable		 3kp2A-4o0mA:
15.42
3kp2B-4o0mA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 9 ILE A 131
ALA A 169
THR A  42
VAL A 148
VAL A  75
 None
 1.23A 3me6C-4o0mA:
undetectable		 3me6C-4o0mA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		4 / 5 VAL A 298
LEU A 302
ILE A 346
ALA A 316
 None
 0.92A 3n8yB-4o0mA:
undetectable		 3n8yB-4o0mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 10 ILE A 346
ALA A 376
LEU A 344
LEU A 302
VAL A 298
 None
 1.24A 3o02A-4o0mA:
undetectable
3o02B-4o0mA:
undetectable		 3o02A-4o0mA:
20.08
3o02B-4o0mA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		3 / 3 LYS A 404
THR A 400
ILE A 430
 None
None
SEP  A 431 ( 3.7A)
 0.88A 4e0fB-4o0mA:
undetectable		 4e0fB-4o0mA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 10 THR A 295
SER A 299
ALA A 376
ALA A 316
ILE A 346
 MG  A 801 ( 3.1A)
None
None
None
None
 0.96A 4lbgA-4o0mA:
2.8		 4lbgA-4o0mA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		4 / 5 GLY A 355
ILE A 362
LYS A 364
GLN A 361
 None
 1.13A 4ma8C-4o0mA:
undetectable		 4ma8C-4o0mA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 12 GLY A 401
GLN A 256
MET A 252
LEU A 254
ILE A 430
 None
None
None
None
SEP  A 431 ( 3.7A)
 1.25A 4p6xE-4o0mA:
undetectable		 4p6xE-4o0mA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 12 GLY A 120
GLN A 154
VAL A 118
PHE A 152
LEU A 127
 None
 0.88A 5uc3B-4o0mA:
undetectable		 5uc3B-4o0mA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 12 VAL A 148
ILE A 145
ILE A 131
LEU A 127
VAL A 151
 None
 0.96A 5uvmB-4o0mA:
undetectable		 5uvmB-4o0mA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		3 / 3 SER A 353
HIS A 359
TYR A 317
 None
 1.02A 5y2tA-4o0mA:
undetectable		 5y2tA-4o0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Thermosynechococ
cus
elongatus) 		5 / 10 ASP A 435
THR A 409
THR A 400
GLY A 401
GLU A 406
 None
 1.01A 6mb9C-4o0mA:
undetectable		 6mb9C-4o0mA:
11.37