SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 10 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.87A 1muiA-4o1eA:
undetectable		 1muiA-4o1eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.87A 1muiB-4o1eA:
undetectable		 1muiB-4o1eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 11 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.85A 1ohrA-4o1eA:
undetectable		 1ohrA-4o1eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		8 / 12 ASN A  10
ASP A  76
ASN A  97
ILE A 121
ASP A 161
GLY A 196
SER A 198
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
C2F  A3000 (-4.3A)
 1.11A 1q8jA-4o1eA:
29.8		 1q8jA-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		8 / 12 ASP A  76
ASN A  97
ILE A 121
ASP A 161
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.14A 1q8jA-4o1eA:
29.8		 1q8jA-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		8 / 12 GLU A   7
ASN A  10
ASP A  76
ASN A  97
ILE A 121
ASP A 161
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.55A 1q8jA-4o1eA:
29.8		 1q8jA-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 ASN A  10
ASN A  97
SER A  98
ILE A 121
SER A 198
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.0A)
None
C2F  A3000 ( 4.1A)
C2F  A3000 ( 3.8A)
C2F  A3000 (-4.3A)
 1.10A 1q8jB-4o1eA:
12.7		 1q8jB-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  10
ASP A  76
ASN A  97
ILE A 121
GLY A 196
SER A 198
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
C2F  A3000 (-4.3A)
 1.17A 1q8jB-4o1eA:
12.7		 1q8jB-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 ASP A  76
ASN A  97
ILE A 121
GLY A 196
ASN A 199
ARG A 207
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
 1.06A 1q8jB-4o1eA:
12.7		 1q8jB-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 ASP A  76
ASN A  97
ILE A 121
GLY A 196
SER A 198
ARG A 207
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
 1.23A 1q8jB-4o1eA:
12.7		 1q8jB-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ASN A  97
SER A  98
ILE A 121
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.0A)
None
C2F  A3000 ( 4.1A)
C2F  A3000 (-4.3A)
 0.73A 1q8jB-4o1eA:
12.7		 1q8jB-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 GLU A   7
ASN A  10
ASP A  76
ASN A  97
ILE A 121
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.52A 1q8jB-4o1eA:
12.7		 1q8jB-4o1eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.88A 1rl8A-4o1eA:
undetectable		 1rl8A-4o1eA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 11 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.85A 1sdvB-4o1eA:
undetectable		 1sdvB-4o1eA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 10 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.89A 2aquA-4o1eA:
undetectable		 2aquA-4o1eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 11 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.90A 2aquB-4o1eA:
undetectable		 2aquB-4o1eA:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 ASN A  97
ILE A 121
LEU A 123
GLY A 196
ASN A 199
ARG A 207
 C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
 0.82A 2e7fA-4o1eA:
33.9		 2e7fA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  76
ASN A  97
ILE A 121
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.15A 2e7fA-4o1eA:
33.9		 2e7fA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 0.85A 2e7fA-4o1eA:
33.9		 2e7fA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 GLU A   7
ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.54A 2e7fA-4o1eA:
33.9		 2e7fA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 ASN A  97
ILE A 121
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.10A 2e7fB-4o1eA:
34.0		 2e7fB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  97
ILE A 121
LEU A 123
GLY A 196
ASN A 199
ARG A 207
ILE A 227
 C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
C2F  A3000 (-4.3A)
 0.84A 2e7fB-4o1eA:
34.0		 2e7fB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.50A 2e7fB-4o1eA:
34.0		 2e7fB-4o1eA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 11 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.89A 2fxeB-4o1eA:
undetectable		 2fxeB-4o1eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.85A 2o4kB-4o1eA:
undetectable		 2o4kB-4o1eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.87A 2o4sB-4o1eA:
undetectable		 2o4sB-4o1eA:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  76
ASN A  97
ILE A 121
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.13A 2ogyA-4o1eA:
33.7		 2ogyA-4o1eA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 0.87A 2ogyA-4o1eA:
33.7		 2ogyA-4o1eA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 GLU A   7
ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.58A 2ogyA-4o1eA:
33.7		 2ogyA-4o1eA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  76
ASN A  97
ILE A 121
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.09A 2ogyB-4o1eA:
33.8		 2ogyB-4o1eA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 0.84A 2ogyB-4o1eA:
33.8		 2ogyB-4o1eA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 GLU A   7
ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.54A 2ogyB-4o1eA:
33.8		 2ogyB-4o1eA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ARG A  34
GLY A  39
ALA A  40
ASP A  41
ILE A   5
 None
 0.95A 2q5kB-4o1eA:
undetectable		 2q5kB-4o1eA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.83A 2r5pB-4o1eA:
undetectable		 2r5pB-4o1eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.83A 2r5pD-4o1eA:
undetectable		 2r5pD-4o1eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 11 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.89A 2r5qB-4o1eA:
undetectable		 2r5qB-4o1eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 10 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.88A 2r5qD-4o1eA:
undetectable		 2r5qD-4o1eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.88A 2rkgB-4o1eA:
undetectable		 2rkgB-4o1eA:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  97
ILE A 121
LEU A 123
ASP A 161
GLY A 196
ASN A 199
ILE A 227
 C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
C2F  A3000 (-4.3A)
 0.75A 2ycjA-4o1eA:
35.3		 2ycjA-4o1eA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASN A  97
ILE A 121
LEU A 123
ASP A 161
ILE A   5
 C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
None
 1.20A 2ycjA-4o1eA:
35.3		 2ycjA-4o1eA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  76
ASN A  97
ILE A 121
ASP A 161
GLY A 196
SER A 198
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
C2F  A3000 (-4.3A)
 1.07A 2ycjA-4o1eA:
35.3		 2ycjA-4o1eA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  76
ASN A  97
ILE A 121
LEU A 123
ASP A 161
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.51A 2ycjA-4o1eA:
35.3		 2ycjA-4o1eA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 228
VAL A 164
ASP A 224
LEU A 215
LEU A 239
 None
 1.02A 3cjtC-4o1eA:
undetectable		 3cjtC-4o1eA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.91A 3cyxB-4o1eA:
undetectable		 3cyxB-4o1eA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 10 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.85A 3ekyA-4o1eA:
undetectable		 3ekyA-4o1eA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 11 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.90A 3em4A-4o1eA:
undetectable		 3em4A-4o1eA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 11 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.84A 3em4U-4o1eA:
undetectable		 3em4U-4o1eA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 10 ILE A 130
PRO A 131
SER A 128
GLY A 129
SER A 100
 None
 1.11A 3ik6B-4o1eA:
undetectable
3ik6E-4o1eA:
undetectable		 3ik6B-4o1eA:
21.36
3ik6E-4o1eA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 10 SER A 100
ILE A 130
PRO A 131
SER A 128
GLY A 129
 None
 1.15A 3ik6B-4o1eA:
undetectable
3ik6E-4o1eA:
undetectable		 3ik6B-4o1eA:
21.36
3ik6E-4o1eA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASN A  10
ASP A  76
GLY A 196
SER A 198
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
C2F  A3000 (-4.3A)
 1.26A 3k13A-4o1eA:
27.8		 3k13A-4o1eA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASN A  10
ASP A  76
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.61A 3k13A-4o1eA:
27.8		 3k13A-4o1eA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		3 / 3 ASN A  97
ASP A 161
ARG A 207
 C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
None
 0.48A 3k13A-4o1eA:
27.8		 3k13A-4o1eA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  10
ASP A  76
ASN A  97
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.17A 3k13B-4o1eA:
27.8		 3k13B-4o1eA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ASP A  76
ASN A  97
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.60A 3k13B-4o1eA:
27.8		 3k13B-4o1eA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 ASN A  10
ASP A  76
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.21A 3k13C-4o1eA:
27.7		 3k13C-4o1eA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASN A  10
ASP A  76
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.64A 3k13C-4o1eA:
27.7		 3k13C-4o1eA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.83A 3oxxC-4o1eA:
undetectable		 3oxxC-4o1eA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		3 / 3 ASP A  44
GLU A  54
SER A 225
 None
 0.70A 3p2kA-4o1eA:
undetectable		 3p2kA-4o1eA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 10 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.92A 3ttpA-4o1eA:
undetectable		 3ttpA-4o1eA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 10 ASP A 170
GLY A 172
ALA A 173
PRO A 131
ILE A 165
 None
 0.96A 3ttpB-4o1eA:
undetectable		 3ttpB-4o1eA:
16.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  10
ASP A  76
ASP A 161
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.18A 4djeA-4o1eA:
34.0		 4djeA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  10
ASP A  76
LEU A 123
ASP A 161
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 1.00A 4djeA-4o1eA:
34.0		 4djeA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 GLU A   7
ASN A  10
ASP A  76
LEU A 123
ASP A 161
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.66A 4djeA-4o1eA:
34.0		 4djeA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASN A  97
ASP A 161
GLY A 196
ASN A 199
ARG A 207
 C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
 0.96A 4djeB-4o1eA:
33.4		 4djeB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 ASP A  44
ASP A  76
ASN A  97
ASP A 161
GLY A 196
ARG A 207
 None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
None
 1.01A 4djeB-4o1eA:
33.4		 4djeB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A  44
ASP A  76
GLY A 196
SER A 198
ARG A 207
 None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
 1.15A 4djeB-4o1eA:
33.4		 4djeB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASP A  44
ASP A  76
ASN A  97
ASP A 161
GLY A 196
 C2F  A3000 (-3.6A)
None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
 0.60A 4djeB-4o1eA:
33.4		 4djeB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  10
ILE A 121
ASP A 161
GLY A 196
ASN A 199
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
C2F  A3000 (-4.3A)
 1.00A 4djfA-4o1eA:
34.0		 4djfA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 ASN A  10
ILE A 121
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.25A 4djfA-4o1eA:
34.0		 4djfA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ILE A 121
ASP A 161
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.47A 4djfA-4o1eA:
34.0		 4djfA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASP A  44
ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ARG A 207
 None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
None
 0.95A 4djfB-4o1eA:
33.7		 4djfB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASP A  44
ASP A  76
GLY A 196
SER A 198
ARG A 207
 None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
 1.05A 4djfB-4o1eA:
33.7		 4djfB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 GLU A   7
ASP A  44
ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
 C2F  A3000 (-3.6A)
None
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
 0.47A 4djfB-4o1eA:
33.7		 4djfB-4o1eA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 4 ILE A  13
SER A  15
ASP A 229
ASP A 234
 C2F  A3000 ( 4.4A)
None
C2F  A3000 (-3.7A)
None
 1.19A 4krhB-4o1eA:
undetectable		 4krhB-4o1eA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 5 GLN A  35
THR A 194
HIS A 159
LEU A  95
 None
 1.03A 4lvcC-4o1eA:
2.2		 4lvcC-4o1eA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  10
ILE A  13
ASP A  44
ILE A 121
ASP A 161
GLY A 196
SER A 198
 C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
None
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
 1.31A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		12 / 12 GLU A   7
ASN A  10
ILE A  13
ASP A  76
ILE A 121
LEU A 123
ASP A 161
GLY A 196
SER A 198
LYS A 208
ILE A 227
ASN A 232
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
C2F  A3000 (-3.6A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
C2F  A3000 (-3.8A)
C2F  A3000 (-4.3A)
C2F  A3000 (-4.0A)
 0.14A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ILE A  13
LEU A 163
ASP A 161
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 1.26A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		3 / 3 LYS A   8
ASN A  97
ASP A 229
 C2F  A3000 (-2.7A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.7A)
 0.00A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		7 / 12 ASN A  10
ILE A  13
ASP A  44
ILE A 121
GLY A 196
SER A 198
ASN A 199
 C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
None
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
C2F  A3000 ( 4.3A)
 1.33A 4o1eB-4o1eA:
45.8		 4o1eB-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		12 / 12 GLU A   7
ASN A  10
ILE A  13
ASP A  76
ILE A 121
LEU A 123
GLY A 196
SER A 198
ASN A 199
LYS A 208
ILE A 227
ASN A 232
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
C2F  A3000 (-3.6A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
C2F  A3000 ( 4.3A)
C2F  A3000 (-3.8A)
C2F  A3000 (-4.3A)
C2F  A3000 (-4.0A)
 0.29A 4o1eB-4o1eA:
45.8		 4o1eB-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASN A  10
ILE A  13
LEU A 163
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
None
C2F  A3000 (-4.3A)
 0.94A 4o1eB-4o1eA:
45.8		 4o1eB-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 4 LYS A   8
ASN A  97
ASP A 161
ASP A 229
 C2F  A3000 (-2.7A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.7A)
 0.14A 4o1eB-4o1eA:
45.8		 4o1eB-4o1eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLY A  94
ILE A   3
ILE A  43
VAL A  65
ILE A   9
 None
 0.98A 4q5mA-4o1eA:
undetectable		 4q5mA-4o1eA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		3 / 3 GLU A 107
ILE A 140
ALA A 148
 None
 0.58A 4wnwB-4o1eA:
undetectable		 4wnwB-4o1eA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A  43
GLY A   6
ALA A  40
ARG A  34
THR A  71
 None
 1.28A 4xt8A-4o1eA:
undetectable		 4xt8A-4o1eA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.55A 5vooA-4o1eA:
27.8		 5vooA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 5 ASN A  10
ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.25A 5vooA-4o1eA:
27.8		 5vooA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 5 ASP A  76
ASN A  97
ASP A 161
ASN A 199
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
 0.83A 5vooA-4o1eA:
27.8		 5vooA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.52A 5vooB-4o1eA:
27.8		 5vooB-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASN A  10
LEU A 163
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 1.00A 5vooB-4o1eA:
27.8		 5vooB-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 5 ASP A  76
ASN A  97
ASP A 161
ASN A 199
ARG A 207
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
 0.79A 5vooB-4o1eA:
27.8		 5vooB-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.56A 5vooC-4o1eA:
28.0		 5vooC-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 5 ASN A  10
ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.24A 5vooC-4o1eA:
28.0		 5vooC-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 5 ASP A  76
ASN A  97
ASP A 161
ASN A 199
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
 0.76A 5vooC-4o1eA:
28.0		 5vooC-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.57A 5vooD-4o1eA:
27.9		 5vooD-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASN A  10
LEU A 163
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 1.05A 5vooD-4o1eA:
27.9		 5vooD-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 5 ASP A  76
ASN A  97
ASP A 161
ASN A 199
ARG A 207
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
 0.76A 5vooD-4o1eA:
27.9		 5vooD-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.64A 5vooE-4o1eA:
27.8		 5vooE-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 5 ASN A  10
ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 ( 4.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.29A 5vooE-4o1eA:
27.8		 5vooE-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 5 ASP A  76
ASN A  97
ASP A 161
ASN A 199
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
 0.80A 5vooE-4o1eA:
27.8		 5vooE-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASN A  10
LEU A 123
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 1.13A 5vooF-4o1eA:
27.8		 5vooF-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.60A 5vooF-4o1eA:
27.8		 5vooF-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASN A  10
LEU A 163
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 1.17A 5vooF-4o1eA:
27.8		 5vooF-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 4 ASP A  76
ASN A  97
ASP A 161
ASN A 199
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
 0.83A 5vooF-4o1eA:
27.8		 5vooF-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASN A  10
LEU A 123
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 0.94A 5vopA-4o1eA:
28.2		 5vopA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.54A 5vopA-4o1eA:
28.2		 5vopA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASN A  10
LEU A 163
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.95A 5vopA-4o1eA:
28.2		 5vopA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		3 / 3 ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.26A 5vopA-4o1eA:
28.2		 5vopA-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ASN A  10
LEU A 123
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 1.14A 5vopB-4o1eA:
27.9		 5vopB-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		6 / 12 GLU A   7
ASN A  10
ASP A  44
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.71A 5vopB-4o1eA:
27.9		 5vopB-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 GLU A   7
ASN A  10
LEU A 163
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 1.17A 5vopB-4o1eA:
27.9		 5vopB-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		3 / 3 ASP A  76
ASN A  97
ASP A 161
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.5A)
 0.27A 5vopB-4o1eA:
27.9		 5vopB-4o1eA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		5 / 12 ARG A  34
GLY A  39
ALA A  40
ASP A  41
ILE A   5
 None
 0.91A 6dj1B-4o1eA:
undetectable		 6dj1B-4o1eA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4o1e DIHYDROPTEROATE
SYNTHASE DHPS
(Desulfitobacteri
um
hafniense) 		4 / 5 GLN A  35
THR A 194
HIS A 159
LEU A  95
 None
 1.03A 6gbnA-4o1eA:
undetectable		 6gbnA-4o1eA:
22.62