SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4o1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 8 CYH A  56
HIS A 112
CYH A 115
GLY A 116
GLY A 117
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.2A)
None
None
 0.26A 1ekjA-4o1kA:
21.8
1ekjB-4o1kA:
21.4		 1ekjA-4o1kA:
28.57
1ekjB-4o1kA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		4 / 8 CYH A  56
HIS A 112
CYH A 115
GLY A 116
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.2A)
None
 0.27A 1ekjA-4o1kA:
21.8
1ekjB-4o1kA:
21.4		 1ekjA-4o1kA:
28.57
1ekjB-4o1kA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		4 / 8 CYH A  56
HIS A 112
CYH A 115
GLY A 117
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.2A)
None
 0.93A 1ekjA-4o1kA:
21.8
1ekjB-4o1kA:
21.4		 1ekjA-4o1kA:
28.57
1ekjB-4o1kA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		4 / 7 CYH A  56
HIS A 112
GLY A 116
GLY A 117
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
None
None
 0.29A 1ekjE-4o1kA:
21.4
1ekjF-4o1kA:
21.5		 1ekjE-4o1kA:
28.57
1ekjF-4o1kA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 8 CYH A  56
HIS A 112
CYH A 115
GLY A 116
GLY A 117
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.2A)
None
None
 0.30A 1ekjG-4o1kA:
21.7
1ekjH-4o1kA:
21.6		 1ekjG-4o1kA:
28.57
1ekjH-4o1kA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 12 PHE A 196
GLY A 111
GLY A 193
ASN A 197
VAL A 108
 None
 0.98A 2hmyB-4o1kA:
undetectable		 2hmyB-4o1kA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 12 LEU A  83
GLY A  55
VAL A 173
ILE A 191
GLY A 193
 None
 0.97A 2pynB-4o1kA:
undetectable		 2pynB-4o1kA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		4 / 7 LEU A 214
ALA A 184
GLY A 187
PHE A 210
 None
 0.92A 2wq5A-4o1kA:
undetectable		 2wq5A-4o1kA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 12 ILE A 191
GLY A 193
LEU A  83
VAL A  84
ILE A  54
 None
 1.13A 3adsB-4o1kA:
undetectable		 3adsB-4o1kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		3 / 3 CYH A  56
CYH A 115
HIS A 112
 ZN  A 301 (-2.3A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.89A 3dtuB-4o1kA:
undetectable		 3dtuB-4o1kA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		3 / 3 CYH A  56
CYH A 115
HIS A 112
 ZN  A 301 (-2.3A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.87A 3dtuD-4o1kA:
undetectable		 3dtuD-4o1kA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 12 LEU A  83
GLY A  55
VAL A 173
ILE A 191
GLY A 193
 None
 0.98A 3nduC-4o1kA:
undetectable		 3nduC-4o1kA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 12 LEU A  83
GLY A  55
VAL A 173
ILE A 191
GLY A 193
 None
 1.01A 3tkgD-4o1kA:
undetectable		 3tkgD-4o1kA:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 10 CYH A  56
HIS A 112
CYH A 115
GLY A 116
ALA A 120
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.2A)
None
None
 0.32A 3ucjA-4o1kA:
24.8		 3ucjA-4o1kA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 10 CYH A  56
HIS A 112
CYH A 115
GLY A 117
ALA A 121
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.2A)
None
None
 1.10A 3ucjA-4o1kA:
24.8		 3ucjA-4o1kA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 10 CYH A  56
HIS A 112
CYH A 115
GLY A 116
ALA A 120
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.2A)
None
None
 0.35A 3ucjB-4o1kA:
24.7		 3ucjB-4o1kA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 10 CYH A  56
HIS A 112
CYH A 115
GLY A 117
ALA A 121
 ZN  A 301 (-2.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.2A)
None
None
 1.11A 3ucjB-4o1kA:
24.7		 3ucjB-4o1kA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4o1k CARBONIC ANHYDRASE
(Sordaria
macrospora) 		5 / 12 PHE A 196
GLY A 111
GLY A 193
ASN A 197
VAL A 108
 None
 0.97A 6mhtA-4o1kA:
undetectable		 6mhtA-4o1kA:
20.67